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Updated: Nov 23, 2025

Drug-Induced Sleep Endoscopy DISE with Target Controlled Infusion TCI and Bispectral Analysis in Obstructive Sleep Apnea
07:54

Drug-Induced Sleep Endoscopy DISE with Target Controlled Infusion TCI and Bispectral Analysis in Obstructive Sleep Apnea

Published on: December 6, 2016

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Drug-induced sleep endoscopy directed surgery improves polysomnography measures in overweight and obese children with

Natalia Filipek1,2, Erin Kirkham1,2, Maida Chen3

  • 1Department of Otolaryngology-Head and Neck Surgery, University of Washington, Seattle, WA, USA.

Acta Oto-Laryngologica
|December 29, 2020
PubMed

Insights

Drug-induced sleep endoscopy (DISE)-directed surgery significantly improved sleep apnea in obese children. Key polysomnography metrics like apnea-hypopnea index and oxygen saturation showed marked improvements post-intervention.

Area of Science:

  • Pediatric Sleep Medicine
  • Otolaryngology
  • Surgical Interventions

Background:

  • Obstructive sleep apnea (OSA) affects 1-4% of children, with higher prevalence in overweight and obese populations.
  • Obesity is a significant risk factor for pediatric OSA, necessitating effective treatment strategies.

Purpose of the Study:

  • To evaluate the efficacy of drug-induced sleep endoscopy (DISE)-directed surgical interventions for pediatric obstructive sleep apnea.
  • To assess the impact of these surgeries on polysomnography parameters in overweight and obese children.

Main Methods:

  • Retrospective case-series of 40 obese/overweight pediatric patients undergoing DISE-directed surgery.
  • Patients categorized into surgically naive (n=23) and prior adenotonsillectomy (n=17) groups.
  • Comparison of pre- and post-operative polysomnography parameters using statistical tests.

Main Results:

  • Overall significant improvement in apnea-hypopnea index (AHI) from 25.0 to 9.9 events/hour (p < .01).
  • Significant improvement in oxygen nadir from 82.7% to 88.5% (p < .01).
  • Both surgically naive and post-adenotonsillectomy groups showed significant AHI reductions.

Conclusions:

  • DISE-directed surgery leads to significant improvements in polysomnography parameters for obese and overweight children with OSA.
  • Surgical intervention is an effective treatment for improving sleep-disordered breathing in this pediatric population.
Abstract

Keywords:
Sleepapneachildrenendoscopyobesity

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