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Updated: Nov 23, 2025

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Repolarization dispersion in patients with systemic sclerosis.

Udi Nussinovitch1, Gil Beeri2, Shiri Rubin3

  • 1Department of Cardiology, Meir Medical Center, Kfar Saba, Israel;Applicative Cardiovascular Research Center (ACRC), Meir Medical Center, Kfar Saba, Israel;Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.

European Journal of Rheumatology
|December 29, 2020
PubMed
Summary
This summary is machine-generated.

Systemic sclerosis patients show abnormal repolarization markers, but their link to arrhythmias and cardiac death risk needs more study. Further research is recommended for these electrocardiographic findings.

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Area of Science:

  • Cardiology
  • Rheumatology
  • Electrophysiology

Background:

  • Systemic sclerosis (SSc) is linked to higher rates of heart problems and death.
  • The role of specific electrocardiographic (ECG) markers in predicting early cardiac death in SSc patients is debated.

Purpose of the Study:

  • To investigate repolarization markers in SSc patients.
  • To assess the prognostic value of these ECG markers for arrhythmias and cardiac death.

Main Methods:

  • A prospective study included 21 SSc patients and 31 controls.
  • Standardized ECGs were analyzed for repolarization and dispersion parameters using specialized software.
  • Multiple beat averaging was employed for data analysis.

Main Results:

  • SSc patients had significantly higher average QT apex dispersion, JT dispersion, JT corrected dispersion, and Tpeak-Tend corrected compared to controls.
  • No significant differences were found in average QT intervals, corrected QT intervals, QT interval dispersion (QTd), or QT corrected dispersion (QTcd).
  • Late ventricular potentials were absent; one SSc patient with prior arrhythmia showed increased QTd and QTcd, but no arrhythmias occurred during follow-up.

Conclusions:

  • Certain abnormal repolarization parameters are present in SSc patients.
  • The prognostic significance of these findings for ventricular arrhythmias and cardiac death remains undetermined.
  • Additional research is necessary to clarify the clinical implications of these ECG abnormalities in SSc.