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Sensitivity and specificity of increased pulse pressure as a diagnostic test for K/DOQI stage III-b CKD

Ana I Pérez-Castañeda1, Gilberto F Vázquez-de Anda1, Patricia Cerecero-Aguirre1

  • 1Multidisciplinary Health Clinic, Universidad Autónoma del Estado de México, State of Mexico. Mexico.

Gaceta Medica De Mexico
|December 29, 2020
PubMed

Insights

Increased pulse pressure (IPP) can help identify chronic kidney disease (CKD) stage III-b. An IPP of 50 mmHg or higher demonstrated high accuracy in diagnosing this condition.

Area of Science:

  • Nephrology
  • Cardiovascular Medicine
  • Diagnostic Testing

Background:

  • Increased pulse pressure (IPP) is linked to estimated glomerular filtration rates ≤ 60/mL/min/1.73 m².
  • IPP may serve as a diagnostic marker for identifying individuals with K/DOQI stage III-b chronic kidney disease (CKD).

Purpose of the Study:

  • To evaluate the diagnostic utility of IPP for K/DOQI stage III-b CKD.

Main Methods:

  • A diagnostic test study involving adult patients without comorbidities from the Health Workers Cohort.
  • Glomerular filtration was calculated using the CKD-EPI formula.
  • Pulse pressure was calculated as systolic minus diastolic blood pressure. Sensitivity, specificity, predictive values, and prevalence were determined, and a ROC curve was generated.

Main Results:

  • The study included 6,215 patients.
  • An IPP ≥ 50 mmHg showed 74% sensitivity and 70% specificity.
  • The positive predictive value was 1%, the negative predictive value was 100%, and the prevalence was 1%. The ROC curve's inflection point for identifying K/DOQI III-b CKD was 0.71.

Conclusions:

  • An IPP ≥ 50 mmHg is a valuable diagnostic tool for identifying individuals with K/DOQI stage III-b CKD.
Abstract

Keywords:
Diagnostic testFiltración glomerularGlomerular filtrationK/DOQI III-bPresión de pulsoPrueba diagnósticaPulse pressure

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