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Related Concept Videos

Glaucoma: Overview01:25

Glaucoma: Overview

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Glaucoma is an eye condition characterized by increased intraocular pressure that damages the retina and optic nerve, leading to irreversible blindness if left untreated. The human eye has various components, including the cornea, iris, pupil, lens, and optic nerve. Aqueous humor is secreted by the epithelium of the ciliary body in the posterior chamber and flows through the trabecular meshwork and canal of Schlemm, maintaining normal intraocular pressure. The trabecular meshwork and the canal...
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Open Angle Glaucoma: Treatment01:27

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In open-angle glaucoma, the iridocorneal angle remains open, but the trabecular meshwork becomes stiff, slowing down the outflow of aqueous humor. This causes a buildup of aqueous humor in the anterior chamber, leading to a sudden increase in intraocular pressure. The treatment for open-angle glaucoma focuses on reducing the elevated intraocular pressure by either decreasing the secretion of aqueous humor or increasing its outflow.
Drugs such as carbonic anhydrase inhibitors, α2- and...
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Angle Closure Glaucoma: Treatment01:28

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Angle-closure glaucoma, or closed-angle glaucoma, is an eye condition where the iris bulges out and blocks the iridocorneal angle, resulting in a buildup of aqueous humor and increased intraocular pressure. Immediate medical attention is necessary due to the sudden onset of symptoms. The treatment for angle-closure glaucoma includes short-term and long-term approaches. Short-term treatment involves using eye drops like pilocarpine to lower intraocular pressure by increasing aqueous humor...
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Related Experiment Video

Updated: Nov 23, 2025

Assessing Early Stage Open-Angle Glaucoma in Patients by Isolated-Check Visual Evoked Potential
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Focal Structure-Function Relationships in Primary Open-Angle Glaucoma Using OCT and OCT-A Measurements.

Damon Wong1,2,3, Jacqueline Chua3,4, Emily Lin3

  • 1SERI-NTU Advanced Ocular Engineering (STANCE), Singapore.

Investigative Ophthalmology & Visual Science
|December 29, 2020
PubMed
Summary

Focal capillary density, measured by OCT-A, is more strongly associated with visual field loss in glaucoma than nerve fiber layer thickness. This finding highlights the role of vascular changes in glaucoma progression.

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Area of Science:

  • Ophthalmology
  • Neuroscience
  • Medical Imaging

Background:

  • Glaucoma is a leading cause of irreversible blindness worldwide.
  • Early detection and monitoring of glaucoma progression are crucial for preserving vision.
  • Understanding the relationship between structural and functional changes in glaucoma is essential for effective management.

Purpose of the Study:

  • To investigate the associations between visual field (VF) loss and both optical coherence tomography angiography (OCT-A) vascular measurements and optical coherence tomography (OCT) structural measurements in glaucoma.
  • To evaluate focal structure-function relationships in primary open-angle glaucoma (POAG).

Main Methods:

  • Cross-sectional study involving 119 eyes from 86 Chinese subjects with POAG.
  • Standard automated perimetry, OCT, and OCT-A imaging were performed.
  • Multivariate mixed-effects analysis and segmented regression analysis were used to assess structure-function associations.

Main Results:

  • Global capillary perfusion density and retinal nerve fiber layer thickness were significantly associated with VF mean deviation.
  • Focal capillary density (FCD) showed significant associations with VF losses at 66.7% of tested locations, particularly within 20° eccentricity.
  • Focal nerve fiber layer (FNL) thickness was associated with VF losses at 31.4% of tested locations.

Conclusions:

  • Focal capillary densities are associated with a broader range and larger proportion of visual field loss compared to nerve fiber layer thickness in glaucoma.
  • Vascular changes, as assessed by OCT-A, may play a more significant role in the functional deficits of glaucoma than previously recognized.