Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Andrea Forschner1, Stephan Forchhammer2, Irina Bonzheim3

  • 1Zentrum für Dermatoonkologie, Universitäts-Hautklinik Tübingen.

Journal Der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG
|December 29, 2020
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Years of life lost in patients with a false-negative diagnosis of primary melanoma. A prospective study of the German Central Malignant Melanoma Registry involving 9063 patients over 28 years.

Nature communications·2026
Same author

Perioperative PD-1-inhibition in melanoma patients - a retrospective analysis from eight German skin cancer centers.

Journal der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG·2026
Same author

Encorafenib-associated acantholytic dermatosis in collision with eccrine squamous syringometaplasia.

Journal der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG·2026
Same author

Copy Number Analysis in Congenital Nevi: Concordance and Diagnostic Limitations of aCGH, sWGS, and Methylation Sequencing.

Pigment cell & melanoma research·2026
Same author

[Applications and limitations of liquid biopsy : Applications and methodological limitations of cell-free DNA analysis in tumor diagnostics].

Pathologie (Heidelberg, Germany)·2026
Same author

Selective internal radiotherapy and chemosaturation show equivalent survival in metastatic uveal melanoma: a retrospective multicenter study.

The oncologist·2026
Same journal

The different face of skin-rash induced by brentuximab vedotin.

Journal der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG·2026
Same journal

Repositioning Non-Ablative Fractional Lasers - Molecular and Histological Insights from a scoping review.

Journal der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG·2026
Same journal

Infusion-site reactions to foslevodopa/foscarbidopa in Parkinson's disease.

Journal der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG·2026
Same journal

Tranexamic Acid-Soaked Intranasal Packing for Postoperative Bleeding After Nasal Interpolation Flap Repair.

Journal der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG·2026
Same journal

Monoclonal gammopathy of dermatological significance: non-amyloid paraprotein deposits with light and heavy chains.

Journal der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG·2026
Same journal

Papular epidermal nevus with "skyline" basal cell layer: Clinical clues from a three-member family.

Journal der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG·2026
See all related articles

Neurotrophic tyrosine receptor kinase (NTRK) fusions are oncogenic drivers. This study found NTRK fusions are relatively common in Spitzoid melanoma, suggesting TRK inhibitors may benefit these patients.

Area of Science:

  • Oncology
  • Molecular Biology
  • Genetics

Context:

  • Neurotrophic tyrosine receptor kinase (NTRK) gene fusions are established oncogenic drivers in various cancers, including rare instances in melanoma.
  • High incidences of NTRK fusions are reported in infantile fibrosarcoma and secretory breast carcinoma.
  • The recent approval of Larotrectinib, a Tropomyosin receptor kinase (TRK) inhibitor, prompts investigation into their relevance for melanoma patients.

Purpose:

  • To investigate the prevalence and clinical relevance of NTRK gene fusions in different melanoma subtypes.
  • To explore the potential of TRK inhibitors as a therapeutic strategy for melanoma patients with NTRK fusions.

Summary:

  • NTRK fusions occur in 21-29% of Spitzoid melanomas, significantly higher than in cutaneous (<1%), mucosal (<1%), or acral (2.5%) melanomas.

Related Experiment Videos

  • NTRK fusions appear to be mutually exclusive with other common drivers like BRAF and NRAS.
  • Low tumor mutational burden may indicate a higher likelihood of NTRK-positive tumors.

    • Impact:

    • Identifies a potential therapeutic target and patient population for TRK inhibitors in melanoma.
    • Highlights the need for integrating NTRK fusion screening into clinical practice for melanoma management.
    • Suggests screening BRAF, NRAS, and KIT wild-type melanoma patients with Next-Generation Sequencing upon requiring systemic therapy or upon lack of response to checkpoint inhibitors.