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Navya Gupta1, Anuradha Bishnoi2, Don Mathew1

  • 1Department of Biochemistry, Postgraduate Institute of Medical Education and Research, Chandigarh, India.

Journal Der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG
|December 29, 2020
PubMed
Summary
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The CC genotype of MMP-2 (-1306 C/T) single nucleotide polymorphism (SNP) is associated with an increased risk of developing hypertrophic acne scars. This finding may help predict acne scarring risk.

Area of Science:

  • Genetics and Molecular Biology
  • Dermatology
  • Biochemistry

Context:

  • Acne vulgaris is a common skin condition often leading to scarring.
  • Matrix metalloproteinases (MMPs) and their inhibitors (TIMPs) play a role in tissue remodeling and scar formation.
  • Genetic variations, specifically single nucleotide polymorphisms (SNPs), may influence individual susceptibility to acne and scarring.

Purpose:

  • To investigate the association between specific SNPs in MMP-2 (rs243865) and TIMP-2 (rs8179090) and the development of acne and post-acne scars.
  • To determine if genetic polymorphisms in MMP-2 and TIMP-2 are linked to different types of acne scars (atrophic vs. hypertrophic).

Summary:

  • A study involving 512 acne patients and 161 controls genotyped for MMP-2 (-1306 C/T) and TIMP-2 (-418 G/C) SNPs.
Keywords:
MMP-2-PolymorphismusTIMP-2-PolymorphismusGenotypisierungMatrix-Metalloproteinase-2PhänotypisierungPost-Akne-Narben

Related Experiment Videos

  • Men showed a higher risk for severe acne, facial acne, and facial scarring.
  • A significant association was found between the homozygous CC genotype of MMP-2 (-1306 C/T) and the formation of hypertrophic post-acne scars, with a 7.8-fold increased risk compared to acne patients without scars and an 8.2-fold increased risk compared to those with atrophic scars.

    • Impact:

    • Identifies a specific genetic marker (MMP-2 -1306 C/T CC genotype) associated with hypertrophic acne scarring.
    • Suggests potential for genetic predisposition assessment in acne patients.
    • Contributes to understanding the molecular mechanisms underlying acne scar development.