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The Taming of the Screw: the natural and artificial development of β-propeller proteins
Bram Mylemans1, Arnout Rd Voet2, Jeremy Rh Tame2
1Laboraotry for biomolecular modelling and design, KU Leuven, Celestijnenlaan 200G, 3001 Leuven, Belgium.
Abstract:
Many proteins are found to possess repeated structural elements, which hint at ancient evolutionary origins and ongoing evolutionary processes. β-propeller proteins are a large family of such proteins, and a popular focus of structural analysis. This review highlights recent work to understand how they arose, and how they have developed into one of the most successful of all protein folds.
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