Bile Acid Conjugates with Anticancer Activity: Most Recent Research.

Area of Science:

• Pharmacology
• Organic Chemistry
• Medicinal Chemistry

Background:

• Combination therapy in cancer treatment offers synergistic advantages.
• Bile acids possess unique biological properties and reactive chemical structures.
• Hybrid molecules are increasingly explored for advanced pharmacological applications.

Purpose of the Study:

• To review recent advancements in hybrid molecules derived from bile acids.
• To highlight the potential of bile acids as scaffolds for novel drug conjugates.
• To explore the pharmacological utility of bile acid-based hybrid compounds.

Main Methods:

• Literature review of scientific publications on bile acid hybrid molecules.
• Analysis of chemical structures and biological activities of reported compounds.
• Synthesis strategies for conjugating bile acids with bioactive molecules were examined.

Main Results:

• Bile acids serve as versatile platforms for creating hybrid molecules.
• Conjugation with natural or synthetic bioactive molecules is feasible.
• These hybrid compounds show potential for diverse pharmacological applications.

Conclusions:

• Bile acid-based hybrid molecules represent a promising area for drug discovery.
• Their inherent biological properties and chemical reactivity facilitate the development of novel therapeutics.
• Further research into bile acid conjugation holds significant potential for cancer therapy and beyond.