Related Experiment Video
Updated: Nov 23, 2025
12:40
Isolation and Expansion of Mesenchymal Stem/Stromal Cells Derived from Human Placenta Tissue
Published on: June 6, 2016
37.6K
Current Status and Future Prospects of Perinatal Stem Cells
Paz de la Torre1, Ana I Flores1
1Grupo de Medicina Regenerativa, Instituto de Investigación Sanitaria Hospital 12 de Octubre (imas12), Avda. Cordoba s/n, 28041 Madrid, Spain.
Genes
|December 30, 2020
Summary
Perinatal tissues, including the placenta and cord blood, are rich sources of stem cells for regenerative medicine. These cells show therapeutic potential for various diseases and are being explored in clinical trials, including for COVID-19.
Area of Science:
- Perinatal stem cell research
- Regenerative medicine
- Tissue engineering
Background:
- The placenta, a temporary organ, is a valuable source of stem and progenitor cells.
- Perinatal tissues contain diverse cell types with therapeutic potential beyond cord blood.
- Mesenchymal stromal cells are frequently used in perinatal cell therapy.
Purpose of the Study:
- To review perinatal tissues and stem cells for regenerative medicine.
- To discuss phenotypical characteristics and preclinical applications.
- To provide an overview of clinical trials and future directions.
Main Methods:
- Literature review of perinatal stem cell research.
- Analysis of phenotypical characteristics of isolated cells.
- Overview of preclinical and clinical applications.
Main Results:
- Various stem and progenitor cell types can be isolated from perinatal tissues.
- Perinatal stem cells have shown promise in preclinical models for numerous pathologies.
- Clinical trials are investigating their use in conditions like COVID-19 pneumonia.
Conclusions:
- Perinatal stem cells offer significant potential for cell therapy and regenerative medicine.
- New technologies are advancing the field of perinatal stem cell research.
- Challenges and future directions are critical for progress in this area.
Keywords:
COVID-19amniotic fluid/membranechoriondeciduamesenchymal stromal cellsnanomedicineperinatal tissuesplacentaregenerative medicineumbilical cord tissue/bloodMore Related Videos
Related Concept Videos
01:17Stem Cell Culture
5.8K
Stem cell research aims to find ways to use stem cells to regenerate and repair cellular damage. Over time, most adult cells undergo the wear and tear of aging and lose their ability to divide and repair themselves. Stem cells do not display a particular morphology or function. Adult stem cells, which exist as a small subset of cells in most tissues, keep dividing and can differentiate into a number of specialized cells generally formed by that tissue. These cells enable the body to renew and...
5.8K
00:57Embryonic Stem Cells
4.3K
Embryonic stem (ES) cells were first discovered in mice in 1981 by Martin Evans. In 1998, James Thomson identified a method to isolate embryonic stem cells from humans. Human embryonic stem cells (hESCs) are obtained from 3-5 day old embryos that remain unused after an in vitro fertilization procedure.
ES cells are grown in a culture medium where they can divide indefinitely, creating ES cell lines. Under certain conditions, ES cells can differentiate, either spontaneously into a variety of...
ES cells are grown in a culture medium where they can divide indefinitely, creating ES cell lines. Under certain conditions, ES cells can differentiate, either spontaneously into a variety of...
4.3K
00:58Embryonic Stem Cells
30.4K
Embryonic stem (ES) cells are undifferentiated pluripotent cells, meaning they can produce any cell type in the body. This gives them tremendous potential in science and medicine since they can generate specific cell types for use in research or to replace body cells lost due to damage or disease.
30.4K
01:06Induced Pluripotent Stem Cells
4.9K
Stem cells are undifferentiated cells that divide and produce different cell types. Ordinarily, cells that have differentiated into a specific cell type are terminally differentiated; however, scientists have found a way to reprogram these mature cells so that they dedifferentiate and return to an unspecialized, proliferative state. These cells are pluripotent like embryonic stem cells—able to produce all cell types—and are called induced pluripotent stem cells (iPSCs).
Somatic...
Somatic...
4.9K
01:13Induced Pluripotent Stem Cells
25.6K
Stem cells are undifferentiated cells that divide and produce different types of cells. Ordinarily, cells that have differentiated into a specific cell type are post-mitotic—that is, they no longer divide. However, scientists have found a way to reprogram these mature cells so that they “de-differentiate” and return to an unspecialized, proliferative state. These cells are also pluripotent like embryonic stem cells—able to produce all cell types—and are therefore...
25.6K
01:27Source And Potency Of Stem Cells
5.7K
Stem cells are undifferentiated cells with extensive self-renewal properties that help them maintain their population during the fetal and adult stages of life. They can specialize in all cell types of the human body. However, their differential potential may vary and can be classified into five types. Stem cells can be (1) Totipotent, (2) Pluripotent, (3) Multipotent, (4) Oligopotent, and (5) Unipotent. Each stem cell has a specific origin; the fertilized egg or zygote is a totipotent cell and...
5.7K