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Oromucosal as an Alternative Method for Administration of Cannabis Products in Rodents
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(Endo)Cannabinoids and Gynaecological Cancers.
Anthony H Taylor1,2, Daniel Tortolani3, Thangesweran Ayakannu1,4,5
1Endocannabinoid Research Group, Reproductive Sciences Section, Department of Cancer Studies and Molecular Medicine, University of Leicester, Leicester LE1 7RH, UK.
Cancers
|December 30, 2020
Summary
The endocannabinoid system (ECS) plays a role in gynecological cancer. This review explores cannabinoids
Area of Science:
- Gynecologic Oncology
- Endocrinology
- Pharmacology
Background:
- Gynaecological cancers encompass primary and secondary neoplasms.
- Aetiopathogenesis is multifactorial, involving exogenous and endogenous factors.
- The endocannabinoid system (ECS) is implicated in gynaecological cancer progression.
Purpose of the Study:
- To review the impact of plant-derived cannabinoids and endocannabinoids on gynaecological cancers.
- To discuss the role of ECS proteins in cannabinoid binding, transport, and metabolism.
- To explore the potential of ECS components as cancer biomarkers and therapeutic targets.
Main Methods:
- Literature review focusing on the endocannabinoid system and gynaecological cancers.
- Analysis of the interplay between cannabinoids, ECS components, and cancer progression.
- Examination of ECS elements as potential biomarkers and therapeutic targets.
Main Results:
- Cannabinoids and endocannabinoids influence gynaecological cancer pathogenesis and progression.
- ECS proteins are crucial for cannabinoid activity in reproductive tissues.
- Endocannabinoids, receptors, and enzymes show potential as biomarkers, particularly for endometrial cancer.
Conclusions:
- Targeting the ECS offers potential for novel therapeutic strategies in gynaecological cancers.
- Further research into ECS components may yield innovative drug development opportunities.
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