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Peptide-derived Method to Transport Genes and Proteins Across Cellular and Organellar Barriers in Plants

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Multifunctional Delivery Systems for Peptide Nucleic Acids.

Stefano Volpi¹, Umberto Cancelli¹, Martina Neri¹

¹Department of Chemistry, Life Sciences and Environmental Sustainability, University of Parma, 43124 Parma, Italy.

Pharmaceuticals (Basel, Switzerland)

|December 30, 2020

Summary

This summary is machine-generated.

Peptide nucleic acids (PNAs) show increasing applications, driving the development of advanced delivery systems. This review highlights novel carriers, including nanoparticles and self-assembled systems, enhancing PNA research and therapeutic strategies.

Keywords:

conjugates delivery multifunctional systems nanoparticles peptide nucleic acids

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Area of Science:

Biotechnology and Nanomedicine
Oligonucleotide Analog Delivery

Background:

Peptide nucleic acids (PNAs), with polyamide backbones, are increasingly used in vitro and cellular systems.
The development of effective delivery systems is crucial for PNA applications.

Purpose of the Study:

To provide an overview of available carriers for PNA delivery.
To emphasize newly developed multi-component and multifunctional vehicles for PNA research.

Main Methods:

Review of PNA delivery strategies including conjugation, liposomes, polymer nanoparticles, inorganic porous nanoparticles, carbon-based nanocarriers, and self-assembled systems.
Discussion of emerging therapeutic strategies enabled by PNA-delivery system combinations.

Main Results:

Various carrier systems have been developed to facilitate PNA delivery to target sites.
Multifunctional and multi-component vehicles are significantly advancing PNA research.

Conclusions:

Effective PNA delivery is essential for expanding their therapeutic potential.
Novel carrier systems are crucial for unlocking new therapeutic strategies using PNAs.