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Progress in understanding COVID-19: insights from the omics approach
Baoxu Lin1, Jianhua Liu1, Yong Liu1
1Department of Laboratory Medicine, Shengjing Hospital of China Medical University, Shenyang, China.
Critical Reviews in Clinical Laboratory Sciences
|December 30, 2020
Summary
Omics approaches reveal SARS-CoV-2 molecular characteristics and COVID-19 patient changes. This research aids in developing diagnostic assays, biomarkers, and treatments for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and coronavirus disease (COVID-19).
Area of Science:
- Virology
- Genomics
- Biochemistry
Background:
- Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic necessitates understanding its molecular mechanisms.
- Elucidating SARS-CoV-2 pathology in humans remains a significant challenge.
- Omics approaches offer a powerful tool for molecular characterization and pathophysiology studies.
Purpose of the Study:
- To review omics-based strategies for SARS-CoV-2 detection (antigens and antibodies).
- To summarize metabolomic and proteomic alterations in COVID-19 patients.
- To discuss the progress of anti-SARS-CoV-2 drug research and clinical applications.
Main Methods:
- Review of omics-scale research on SARS-CoV-2 and COVID-19.
- Analysis of strategies for viral detection and biomarker discovery.
- Examination of metabolomic, proteomic, and therapeutic research.
Main Results:
- Omics research accelerates the development of diagnostic assays for SARS-CoV-2.
- Identification of potential biomarkers for assessing COVID-19 disease progression.
- Progress in discovering therapeutic drugs and vaccines against SARS-CoV-2.
Conclusions:
- Omics approaches are vital for understanding SARS-CoV-2 and COVID-19.
- This research provides a foundation for improved diagnostics, prognostics, and therapeutics.
- Continued omics research holds promise for controlling the COVID-19 pandemic.
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