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Nerve growth factor in the equine joint.

A Kendall1, S Nyström2, S Ekman1

  • 1Division of Pathology, Pharmacology and Toxicology, Department of Biomedical Sciences and Veterinary Public Health, Swedish University of Agricultural Sciences, Box 7028, 750 07 Uppsala, Sweden.

Veterinary Journal (London, England : 1997)
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PubMed
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Nerve growth factor (NGF) is elevated in equine osteoarthritis and septic joints. NGF and its receptors are also present in cartilage, suggesting a role in equine joint disease.

Keywords:
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Area of Science:

  • Veterinary Medicine
  • Biochemistry
  • Immunology

Background:

  • Nerve growth factor (NGF) plays roles in inflammation and pain signaling in humans and dogs.
  • Osteoarthritis is prevalent in horses, but NGF's role in equine joints is unstudied.
  • NGF is implicated in canine and human osteoarthritis synovial fluid.

Purpose of the Study:

  • Quantify NGF in equine synovial fluid from healthy, septic, and osteoarthritic joints.
  • Determine the localization of NGF and its receptors (TrkA, p75NTR) in healthy and osteoarthritic equine cartilage.

Main Methods:

  • ELISA was used to measure NGF concentrations in synovial fluid.
  • Immunohistochemistry was employed to examine NGF, TrkA, and p75NTR in articular cartilage.

Main Results:

  • NGF was detected in equine synovial fluid and cartilage.
  • Synovial fluid NGF concentrations were significantly higher in osteoarthritic and septic joints compared to healthy joints.
  • Increased NGF and receptor staining was observed in osteoarthritic cartilage.

Conclusions:

  • NGF is present in equine joints and elevated in osteoarthritis and septic inflammation.
  • NGF and its receptors are localized in equine articular cartilage.
  • Further research should investigate NGF precursor forms and downstream receptor signaling.