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Related Concept Videos

The Nucleus01:25

The Nucleus

6.8K
The nucleus is a membrane-bound organelle that acts as a control center in a eukaryotic cell. It contains chromosomal DNA, which controls gene expression and precisely regulates the production of proteins within the cell. In contrast, the DNA inside the mitochondria and chloroplast only carries out functions that are specific to those organelles.
Arrangement of DNA within Nucleus
The regulation of gene expression inside the nucleus is dependent on many factors, including the DNA structure. The...
6.8K
The Nucleus01:32

The Nucleus

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The nucleus is a membrane-bound organelle that acts as a control center in a eukaryotic cell. It contains chromosomal DNA, which controls gene expression and precisely regulates the production of proteins within the cell. In contrast, the DNA inside the mitochondria and chloroplast only carries out functions that are specific to those organelles.
Arrangement of DNA within Nucleus
The regulation of gene expression inside the nucleus is dependent on many factors, including the DNA structure. The...
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Atomic Nuclei: Magnetic Resonance01:05

Atomic Nuclei: Magnetic Resonance

970
The number of nuclear spins aligned in the lower energy state is slightly greater than those in the higher energy state. In the presence of an external magnetic field, as the spins precess at the Larmor frequency, the excess population results in a net magnetization oriented along the z axis. When a pulse or a short burst of radio waves at the Larmor frequency is applied along the x axis, the coupling of frequencies causes resonance and flips the nuclear spins of the excess population from the...
970
Atomic Nuclei: Nuclear Relaxation Processes01:23

Atomic Nuclei: Nuclear Relaxation Processes

922
In the absence of an external magnetic field, nuclear spin states are degenerate and randomly oriented. When a magnetic field is applied, the spins begin to precess and orient themselves along (lower energy) or against (higher energy) the direction of the field. At equilibrium, a slight excess population of spins exists in the lower energy state. Because the direction of the magnetic field is fixed as the z-axis,  the precessing magnetic moments are randomly oriented around the z-axis.
922
Additional Subnuclear Structures02:10

Additional Subnuclear Structures

5.0K
The eukaryotic nucleus is a double membrane-bound organelle that contains nearly all of the cell’s genetic material in the form of chromosomes. It is rightly called the “brain” of the cell as it shoulders the responsibility of responding to various physiological processes, stress, altered metabolic conditions, and other cellular signals. 
The nucleus contains many membrane-less subnuclear organelles or nuclear bodies, such as nucleoli, Cajal bodies, speckles,...
5.0K
Additional Subnuclear Structures02:10

Additional Subnuclear Structures

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Related Experiment Video

Updated: Nov 23, 2025

Combining 3D Magnetic Force Actuator and Multi-Functional Fluorescence Imaging to Study Nucleus Mechanobiology
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Combining 3D Magnetic Force Actuator and Multi-Functional Fluorescence Imaging to Study Nucleus Mechanobiology

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Actin on and around the Nucleus.

Patricia M Davidson1, Bruno Cadot1

  • 1INSERM - Sorbonne Université UMR974 - Center for Research in Myology, Paris, France.

Trends in Cell Biology
|December 30, 2020
PubMed
Summary

Actin proteins at the outer nuclear membrane (ONM) can transmit forces directly to the nucleus. This review covers new insights into actin

Area of Science:

  • Cell Biology
  • Molecular Biology
  • Biophysics

Background:

  • Actin is crucial for cellular processes like motility and signaling.
  • Transmembrane actin-binding proteins at the outer nuclear membrane (ONM) suggest direct force transmission to the nucleus.
  • Actin-dependent nucleus displacement was first observed a decade ago.

Purpose of the Study:

  • To review recent developments in understanding actin's role in nuclear mechanics.
  • To explore the mechanisms and new functions of actin in nuclear processes.
  • To discuss actin-binding proteins, tissue specificity, and in vitro study methods.

Main Methods:

  • Literature review of recent research.
  • Analysis of studies on actin-binding proteins and outer nuclear membrane interactions.
Keywords:
Nesprinactinmechanotransductionmitosismyosinnucleus

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A Direct Force Probe for Measuring Mechanical Integration Between the Nucleus and the Cytoskeleton
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A Direct Force Probe for Measuring Mechanical Integration Between the Nucleus and the Cytoskeleton

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Author Spotlight: Elucidating the Dynamics of Mechano-Transduction and Nuclear Agitation in Mouse Oocytes
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Author Spotlight: Elucidating the Dynamics of Mechano-Transduction and Nuclear Agitation in Mouse Oocytes

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  • Examination of methods for in vitro reconstitution and study.

    • Main Results:

    • Actin's role in nucleus displacement, mitosis, meiosis, gene expression, and mechanical responses is increasingly understood.
    • Specific actin-binding proteins involved in these nuclear interactions have been identified.
    • Tissue-specific mechanisms and in vitro models are being developed.

    Conclusions:

    • Actin plays a significant and multifaceted role in nuclear mechanics and cellular responses.
    • Further research into actin-nucleus interactions will illuminate fundamental cellular processes.
    • In vitro studies are essential for dissecting the molecular mechanisms of actin-nucleus force transmission.