Related Experiment Video
Updated: Nov 23, 2025
04:33
Methods for Detecting Cough and Airway Inflammation in Mice
Published on: August 2, 2024
929
Inflammatory Subtypes in Classic Asthma and Cough Variant Asthma
Jie Gao1, Feng Wu1, Sifang Wu1
1Department of Pulmonary and Critical Care Medicine, Huizhou the Third People's Hospital, Guangzhou Medical College, Huizhou 516002, People's Republic of China.
Journal of Inflammation Research
|December 30, 2020
Summary
Cough variant asthma (CVA) and classic asthma (CA) share similarities, with eosinophilic inflammation potentially indicating more severe disease. However, differences in spirometry and bronchial hyper-responsiveness were not significant between subtypes.
Area of Science:
- Pulmonology
- Allergy and Immunology
- Respiratory Medicine
Background:
- Sputum analysis is crucial for defining airway inflammatory phenotypes.
- Cough variant asthma (CVA) is recognized as an early form of classic asthma (CA).
- Understanding the relationship between CVA and CA subtypes is essential for asthma management.
Purpose of the Study:
- To investigate the association between different subtypes of CVA and CA.
- To compare inflammatory markers, bronchial hyper-responsiveness, and spirometry between CVA and CA phenotypes.
Main Methods:
- A cohort of 459 patients diagnosed with CVA and CA was studied.
- Standardized spirometry, methacholine bronchial challenge, and induced sputum analysis were performed.
- Statistical analyses were conducted to compare patient groups.
Main Results:
- Female patients were more prevalent in CVA and eosinophilic CVA compared to CA and noneosinophilic CA.
- Eosinophilic airway inflammation was more frequent in CVA than in CA.
- Bronchial hyper-responsiveness (BHR) was reduced in eosinophilic CVA and CA, but not in noneosinophilic forms. A significant inverse correlation was observed between sputum eosinophil percentage and FEV1 (PD20) in both CVA and CA.
Conclusions:
- Eosinophilia may correlate with increased disease severity in asthma.
- Despite potential severity links, spirometry showed no significant differences between eosinophilic and noneosinophilic groups.
- The observed differences in BHR between eosinophilic and noneosinophilic asthma were not clinically dramatic.
Related Concept Videos
01:26Asthma-II: Pathophysiology and Classification
3.6K
Asthma is a prevalent chronic respiratory condition marked by inflammation and hyperresponsiveness of the airways. Its pathophysiology involves complex interactions among inflammatory pathways, immune responses, and neural mechanisms.
Additionally, environmental and genetic factors play crucial roles in determining an individual's susceptibility to asthma and the severity of their condition.
Critical processes in asthma pathophysiology include:
Additionally, environmental and genetic factors play crucial roles in determining an individual's susceptibility to asthma and the severity of their condition.
Critical processes in asthma pathophysiology include:
3.6K
01:20Asthma: Pathogenesis and Management
979
Asthma is a chronic pulmonary condition involving inflammation of the airways, hyper-reactivity, and reversible obstruction of the airways. This condition can significantly impact a person's quality of life, making breathing difficult and leading to distressing symptoms.
Asthma is classified as allergic and non-allergic. Allergens such as dust mites, pollen, and pet dander trigger allergic asthma, while factors like cold air, intense emotions, or exercise can induce non-allergic asthma.
Asthma is classified as allergic and non-allergic. Allergens such as dust mites, pollen, and pet dander trigger allergic asthma, while factors like cold air, intense emotions, or exercise can induce non-allergic asthma.
979
01:29Asthma-I: Introduction
3.0K
Asthma is a chronic respiratory ailment that requires careful management due to its varying symptoms and influencing factors. It is characterized by airway inflammation, bronchial hyperresponsiveness, and reversible airflow obstruction, leading to symptoms like wheezing, shortness of breath, chest tightness, and coughing. The symptom frequency and intensity may vary considerably over time. It is also linked to immune system responses to allergens and irritants, highlighting the complex...
3.0K
01:24Asthma-III: Symptoms and Complications
2.9K
Asthma, a common chronic respiratory condition, is classified considering the frequency and severity of symptoms alongside lung function impairment. Understanding this classification is essential for appropriate treatment and management. Here's a detailed look at the classification of asthma and its clinical features and complications:
Classification of Asthma
Classification of Asthma
2.9K
01:30Asthma-IV: Diagnostic and Management
2.8K
The diagnosis and management of asthma are comprehensive, encompassing clinical assessments, lung function tests, and pharmacological interventions. Here's an overview:
Clinical Assessment for Asthma:
This is the first step in diagnosing and managing asthma. It includes:
Clinical Assessment for Asthma:
This is the first step in diagnosing and managing asthma. It includes:
2.8K
01:25Antiasthma Drugs: Inhaled Corticosteroids and Glucocorticoids
1.3K
Inhaled corticosteroids (ICS) are anti-inflammatory drugs used primarily in treating persistent asthma and providing long-term maintenance. They target the bronchial mucosa, the lining of the airways, to control inflammation, a critical factor in asthma progression and exacerbation.
ICS work through a multifaceted mechanism of action. They suppress the inflammatory response caused by the proliferation of TH cells. They also reduce the transcription of the IL-2 gene, which is involved in the...
ICS work through a multifaceted mechanism of action. They suppress the inflammatory response caused by the proliferation of TH cells. They also reduce the transcription of the IL-2 gene, which is involved in the...
1.3K