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Macular grid photocoagulation. An experimental study on the primate retina
D J Wilson1, D Finkelstein, H A Quigley
1Department of Ophthalmology, Johns Hopkins Medical Institutions, Baltimore, MD.
Archives of Ophthalmology (Chicago, Ill. : 1960)
|January 1, 1988
Summary
Macular grid photocoagulation reduced retinal capillary area in monkeys. While initial damage to retinal layers occurred, normal appearance was restored by five months, suggesting potential for vision improvement.
Area of Science:
- Ophthalmology
- Retinal Imaging
- Laser Therapy
Background:
- Macular edema, often from branch retinal vein occlusion, can impair vision.
- Grid photocoagulation is a treatment modality for macular edema.
Purpose of the Study:
- To evaluate the effects of argon blue-green laser grid photocoagulation on ocular tissues in normal cynomolgus monkeys.
- To assess the impact on retinal vasculature, retinal pigment epithelium, and choroid.
Main Methods:
- Argon blue-green laser photocoagulation was applied to normal cynomolgus monkey eyes.
- Histological and imaging analyses were performed at various time points post-treatment (3 days, 1 month, 5 months).
Main Results:
- A significant decrease in retinal capillary area was observed at 1 and 5 months post-photocoagulation.
- Transient alterations in photoreceptors and retinal pigment epithelium were noted at 3 days, with normalization by 5 months.
Conclusions:
- Grid photocoagulation causes temporary retinal vascular changes and cellular alterations.
- Findings support the therapeutic potential of grid photocoagulation for macular edema, potentially improving vision through resolution.