Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Cell-mediated Immune Responses01:40

Cell-mediated Immune Responses

80.2K
Overview
80.2K
Cytotoxic T Cells-mediated Immune Response01:27

Cytotoxic T Cells-mediated Immune Response

6.1K
Cytotoxic T cells are a vital component of the immune system. They have the remarkable ability to identify and target antigens on infected or abnormal cells. These antigens often originate from intracellular pathogens such as viruses or abnormal proteins cancer cells produce.
Immunological surveillance is the ability of immune cells to monitor and eliminate infected cells with intracellular pathogens, neoplastically transformed cells, and cells with non-self antigens. Cytotoxic T cells and NK...
6.1K
Immune Response Against Viral Pathogens01:29

Immune Response Against Viral Pathogens

1.3K
The immune system's response to viral infections is a complex and coordinated process involving natural killer (NK) cells, T cell-mediated responses, and antibody-mediated responses.
NK Cells
NK cells are a crucial part of our innate immune system, acting as the first line of defense against viral infections. These cells can recognize and kill infected cells without prior exposure to the virus, effectively slowing down the spread of infection. Additionally, NK cells produce proinflammatory...
1.3K
Humoral Immune Responses01:36

Humoral Immune Responses

80.7K
Overview
80.7K
Antigens Involved in Adaptive Immunity01:26

Antigens Involved in Adaptive Immunity

936
An antigen is any substance the immune system identifies as foreign and potentially harmful to the body, prompting an immune response. Antigens have two functional properties: immunogenicity and reactivity. Immunogenicity is the ability of an antigen to stimulate a specific immune response. At the same time, reactivity describes the antigen's ability to react with the cells and antibodies produced in response to it.
Complete Antigens
Complete antigens possess both immunogenicity and...
936
Vaccinations01:51

Vaccinations

49.4K
Overview
49.4K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Increased ULBP1 by doxorubicin sensitizes neuroblastoma to γδT-cell cytotoxicity.

Journal of immunology (Baltimore, Md. : 1950)·2026
Same author

Clonal expansion and phenotypic alterations of TCR Vβ3<sup>+</sup> T cells in juvenile-onset recurrent respiratory papillomatosis: implications for tumor-associated immunity and chemokine-mediated T-cell trafficking.

Journal of virology·2026
Same author

Association of SCART1<sup>+</sup> T cells with neutrophils and cytokine-mediated induction of immunosuppressive neutrophils in neuroblastoma.

Clinical immunology (Orlando, Fla.)·2026
Same author

Urine proteomics uncovers biomarker candidates for early identifying rituximab beneficiaries in paediatric steroid-resistant immune thrombocytopenia.

British journal of haematology·2025
Same author

Pathogenic mechanisms and clinical insights into <i>B3GALNT2</i>-related alpha-dystroglycanopathies.

Journal of neuromuscular diseases·2025
Same author

Urinary metabolomics predicts early rituximab response in steroid-nonresponsive pediatric patients with primary immune thrombocytopenia.

Annals of hematology·2025
Same journal

Drug-induced hypersensitivity syndrome followed by exacerbation of Crohn's disease.

Pediatric investigation·2026
Same journal

Kaposiform hemangioendothelioma: Diagnosis and treatment.

Pediatric investigation·2026
Same journal

A comprehensive parent training program for parents of neurodivergent children with pathological demand avoidance: The Paradigm Shift Program<sup>®</sup> Pilot Study.

Pediatric investigation·2026
Same journal

Double-chambered left ventricle in a pediatric patient with tuberous sclerosis complex: A case report.

Pediatric investigation·2026
Same journal

Pediatric spinal ependymomas: Long-term surgical outcomes in a cohort of 61 cases.

Pediatric investigation·2026
Same journal

Prevalence of non-alcoholic fatty liver disease and its association with different combinations of weight status and metabolic abnormalities in children aged 6-18 years.

Pediatric investigation·2026
See all related articles

Related Experiment Video

Updated: Nov 23, 2025

Live Imaging and Quantification of Viral Infection in K18 hACE2 Transgenic Mice Using Reporter-Expressing Recombinant SARS-CoV-2
08:41

Live Imaging and Quantification of Viral Infection in K18 hACE2 Transgenic Mice Using Reporter-Expressing Recombinant SARS-CoV-2

Published on: November 5, 2021

3.1K

Cell-mediated immunity to SARS-CoV-2.

Xiaolin Wang1, Jingang Gui1

  • 1Laboratory of Tumor Immunology Beijing Pediatric Research Institute Beijing Children's Hospital Capital Medical University National Center for Children's Health Beijing China.

Pediatric Investigation
|December 30, 2020
PubMed
Summary
This summary is machine-generated.

Host cellular immunity is crucial for controlling COVID-19 by impacting virus replication. This review details immune cell dysfunction during SARS-CoV-2 infection, offering hope for immunotherapy strategies.

Keywords:
COVID‐19Cytokine stormImmunotherapyInnate immuneSARS‐CoV‐2T‐cell exhaustion

More Related Videos

Detection of SARS-CoV-2 Neutralizing Antibodies using High-Throughput Fluorescent Imaging of Pseudovirus Infection
10:25

Detection of SARS-CoV-2 Neutralizing Antibodies using High-Throughput Fluorescent Imaging of Pseudovirus Infection

Published on: June 5, 2021

5.0K
Visualization of SARS-CoV-2 using Immuno RNA-Fluorescence In Situ Hybridization
05:23

Visualization of SARS-CoV-2 using Immuno RNA-Fluorescence In Situ Hybridization

Published on: December 23, 2020

6.4K

Related Experiment Videos

Last Updated: Nov 23, 2025

Live Imaging and Quantification of Viral Infection in K18 hACE2 Transgenic Mice Using Reporter-Expressing Recombinant SARS-CoV-2
08:41

Live Imaging and Quantification of Viral Infection in K18 hACE2 Transgenic Mice Using Reporter-Expressing Recombinant SARS-CoV-2

Published on: November 5, 2021

3.1K
Detection of SARS-CoV-2 Neutralizing Antibodies using High-Throughput Fluorescent Imaging of Pseudovirus Infection
10:25

Detection of SARS-CoV-2 Neutralizing Antibodies using High-Throughput Fluorescent Imaging of Pseudovirus Infection

Published on: June 5, 2021

5.0K
Visualization of SARS-CoV-2 using Immuno RNA-Fluorescence In Situ Hybridization
05:23

Visualization of SARS-CoV-2 using Immuno RNA-Fluorescence In Situ Hybridization

Published on: December 23, 2020

6.4K

Area of Science:

  • Immunology
  • Virology
  • Infectious Diseases

Background:

  • The COVID-19 pandemic, caused by SARS-CoV-2, highlights the need to understand host immune responses.
  • While antibody production is studied, cellular immunity's role in controlling viral spread is critical.

Purpose of the Study:

  • To review recent findings on immune cell dysregulation during SARS-CoV-2 infection.
  • To explore the implications of these dysfunctions for COVID-19 progression and treatment.

Main Methods:

  • Literature review of studies on host immunity and SARS-CoV-2.
  • Analysis of immune cell number, T-helper cell polarization, and cytokine storm involvement.
  • Examination of immune cell exhaustion following chronic viral stimulation.

Main Results:

  • SARS-CoV-2 infection leads to aberrant regulation and dysfunction of various immune cells.
  • Observed dysregulation includes changes in immune cell numbers, Th polarity shifts, and cytokine storm induction.
  • Chronic viral stimulation results in immune cell exhaustion, impairing effective responses.

Conclusions:

  • Understanding immune cell dysfunction is key to managing COVID-19.
  • Immunotherapy approaches targeting host immunity show promise for controlling the pandemic.
  • Further research is needed to overcome challenges in developing effective immunotherapies.