Genetically Engineered Mouse Model of Brainstem High-Grade Glioma
Related Experiment Video
Updated: Nov 23, 2025
Translational Orthotopic Models of Glioblastoma Multiforme
Published on: February 17, 2023
Fernando M Nunez1,2, Jessica C Gauss1,2, Flor M Mendez1,2
1Department of Neurosurgery, University of Michigan Medical School, Ann Arbor, MI 48109, USA.
Abstract:
Brainstem gliomas are aggressive tumors that are more prevalent in pediatric patients. The location of these tumors makes them inoperable, and currently there is no effective treatment. Recent genomic data revealed the unique biology of these tumors. The following protocol provides a method to incorporate these specific genetic lesions in a mouse glioma model. Using this model, the effects of these mutations in tumor progression and response to treatments can be studied within a relevant in vivo context. For complete details on the use and execution of this protocol, please refer to Mendez et al. (2020).
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