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Related Experiment Video

Updated: Nov 23, 2025

Technique of Minimally Invasive Transverse Aortic Constriction in Mice for Induction of Left Ventricular Hypertrophy
08:34

Technique of Minimally Invasive Transverse Aortic Constriction in Mice for Induction of Left Ventricular Hypertrophy

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Modified Protocol for A Mouse Heart Failure Model Using Minimally Invasive Transverse Aortic Constriction.

Bilin Liu1,2, Anqi Li1, Meng Gao1

  • 1Institute for Regenerative Medicine, Shanghai East Hospital, School of Life Sciences and Technology, Tongji University, Shanghai 200092, China.

STAR Protocols
|December 30, 2020
PubMed
Summary

We developed a minimally invasive mouse heart failure model (miTAC). This improved method offers higher survival rates and avoids rib cutting compared to traditional surgical constriction, simplifying heart failure research.

Keywords:
Cell BiologyModel Organisms

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Last Updated: Nov 23, 2025

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Area of Science:

  • Cardiovascular Research
  • Surgical Techniques
  • Animal Models

Background:

  • Standard transverse aortic constriction (TAC) for creating mouse heart failure models is invasive and has limitations.
  • Existing methods often require rib cutting and artificial ventilation, leading to lower survival rates.

Purpose of the Study:

  • To present a modified, minimally invasive protocol for inducing heart failure in mice.
  • To establish minimally invasive transverse aortic constriction (miTAC) as a more effective method than standard TAC.

Main Methods:

  • The study details a modified protocol for minimally invasive transverse aortic constriction (miTAC) in mice.
  • Transthoracic echocardiography and histology are used to verify the successful induction of the heart failure model.

Main Results:

  • Minimally invasive transverse aortic constriction (miTAC) demonstrates higher efficacy in generating a heart failure model compared to open-chest TAC.
  • The miTAC protocol bypasses the need for rib resection and tracheal intubation, resulting in improved survival rates.

Conclusions:

  • The miTAC protocol provides a more effective and safer alternative for creating mouse models of heart failure.
  • This refined technique enhances the reliability and reproducibility of heart failure research in mice.