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Burden of Proof: Evaluating the Efficacy of Tumor Mutational Burden (TMB) in Predicting Response to Immune Checkpoint

James Newman1, Nagashree Seetharamu1, Muhammad Wasif Saif1

  • 1Northwell Health Cancer Institute, Lake Success, NY, USA.

Cancer Medicine Journal
|December 30, 2020
PubMed
Abstract

No abstract available in PubMed .

Keywords:
CancerImmune checkpoint inhibitors (ICIs)Microsatellite instability-high (MSI-H)Microsatellite stable (MSS)POLD1POLETumor mutational burden (TMB)

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Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
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