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Alzheimer's Disease: Treatment

Alzheimer's Disease: Treatment

Alzheimer's Disease (AD), a neurodegenerative disorder, is pathologically identified by amyloid plaques and neurofibrillary tangles composed of tau protein. AD pharmacotherapy aims to manage cognitive symptoms, delay disease progression, and treat behavioral symptoms. The treatment is primarily symptomatic and palliative, with no definitive disease-modifying therapy available. Cholinesterase inhibitors, including donepezil (Aricept), rivastigmine (Exelon), and galantamine (Razadyne), are...

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Analysis of Gene Expression Changes in the Rat Hippocampus After Deep Brain Stimulation of the Anterior Thalamic Nucleus

Analysis of Gene Expression Changes in the Rat Hippocampus After Deep Brain Stimulation of the Anterior Thalamic Nucleus

Published on: March 8, 2015

Deep Brain Stimulation for Alzheimer's Disease: Tackling Circuit Dysfunction.

Jordan Lam^1,2, Justin Lee^1,2, Charles Y Liu^1,2

¹USC Neurorestoration Center, Keck School of Medicine of USC, Los Angeles, CA, 90033, USA.

Neuromodulation : Journal of the International Neuromodulation Society

|December 30, 2020

Summary

Deep brain stimulation (DBS) shows promise for Alzheimer's disease by targeting neural circuit dysfunction. Further research and clinical trials are needed to confirm its efficacy as a novel treatment.

Keywords:

Alzhiemer's disease animal studies circuit dysfunction clinical trials deep brain stimulation neuromodulation

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Area of Science:

Neuroscience
Neurology
Biomedical Engineering

Background:

Alzheimer's disease (AD) presents significant challenges due to ineffective treatments targeting amyloid and tau pathology.
Deep brain stimulation (DBS) has shown success in treating other neurological and psychiatric disorders, prompting interest in its application for AD.

Purpose of the Study:

To review the literature on neural circuit dysfunction in Alzheimer's disease.
To explore the potential of deep brain stimulation (DBS) as a treatment for Alzheimer's disease.

Main Methods:

Literature review of human and animal studies.
Analysis of circuit dysfunction in Alzheimer's disease.
Evaluation of deep brain stimulation (DBS) applications in Alzheimer's disease.

Main Results:

Evidence indicates widespread neural circuit dysfunction in Alzheimer's disease across structural, functional, electrophysiological, and neurotransmitter levels.
Studies suggest that deep brain stimulation (DBS) may restore circuit function in Alzheimer's disease.
Deep brain stimulation (DBS) might potentially slow or reverse the disease's underlying pathophysiology.

Conclusions:

Deep brain stimulation (DBS) represents a novel therapeutic target for Alzheimer's disease by addressing circuit dysfunction.
Further research is required to elucidate the basic pathology of Alzheimer's disease and the mechanisms underlying DBS.
Validation through robust clinical data from ongoing phase III trials is essential to establish DBS efficacy for Alzheimer's disease.