Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Genetic Lingo01:11

Genetic Lingo

111.5K
Overview
111.5K
Genetic Variation01:25

Genetic Variation

1.0K
Genetic variation is the diversity in DNA sequences found among individuals of the same species. This diversity is crucial for a species' survival because it helps organisms adapt to environmental changes. Genetic variation begins with fertilization, where an egg and sperm cell merge. Each of these cells carries 23 chromosomes, up to 46 in the fertilized egg. Chromosomes are long DNA strands that contain genes, the basic units of heredity.
Genes exist in different versions called alleles,...
1.0K
Pleiotropy01:33

Pleiotropy

42.3K
Pleiotropy is the phenomenon in which a single gene impacts multiple, seemingly unrelated phenotypic traits. For example, defects in the SOX10 gene cause Waardenburg Syndrome Type 4, or WS4, which can cause defects in pigmentation, hearing impairments, and an absence of intestinal contractions necessary for elimination. This diversity of phenotypes results from the expression pattern of SOX10 in early embryonic and fetal development. SOX10 is found in neural crest cells that form melanocytes,...
42.3K
Comparing Copy Number Variations and SNPs02:26

Comparing Copy Number Variations and SNPs

18.4K
Sequencing of the human genome has opened up several best-kept secrets of the genome. Scientists have identified thousands of genome variations that exist within a population. These variations can be a single nucleotide or a larger chromosomal variation.
Copy number variations or CNVs are the structural variations that cover more than 1kb of DNA sequence. The single nucleotide polymorphism (SNP), on the other hand, is a single nucleotide change or a point mutation that is found in more than 1%...
18.4K
Single Nucleotide Polymorphisms-SNPs01:05

Single Nucleotide Polymorphisms-SNPs

17.4K
A single nucleotide polymorphism or SNP is a single nucleotide variation at a specific genomic position in a large population. It is the most prevalent type of sequence variation found in the human genome. Point mutations that occur in more than 1% of the population qualify as SNPs. These are present once every 1000 nucleotides on an average in the human genome. Replacement of a purine with another purine (A/G) or a pyrimidine with another pyrimidine (C/T) is known as a transition. In contrast,...
17.4K
Non-LTR Retrotransposons03:18

Non-LTR Retrotransposons

12.6K
As the name suggests, non-LTR retrotransposons lack the long terminal repeats characteristic of the LTR retrotransposons. Additionally, both LTR and non-LTR retrotransposons use distinct mechanisms of mobilization. Non-LTR retrotransposons are further divided into two classes - Long interspersed nuclear elements (LINEs) and short interspersed nuclear elements (SINEs), both of which occur abundantly in most mammals, including humans. Some of the active non-LTR retrotransposons in humans are L1...
12.6K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Advances in repair of non-discoid meniscus injuries in children: a narrative review.

Frontiers in pediatrics·2026
Same author

Anti-SARS-CoV-2 and anticancer properties of triptolide and its derived carbonized nanomaterials.

Cancer letters·2025
Same author

Incidence of periprosthetic joint infection after primary total knee arthroplasty shows significant variation : a synthesis of meta-analysis and bibliometric analysis.

Journal of orthopaedic surgery and research·2024
Same author

EDA Complex-Enabled Annulation to Access CF<sub>2</sub>-Containing Tetralones and Quinazolinones Using Persulfates as Electron Donors.

The Journal of organic chemistry·2024
Same author

Using halofuginone-silver thermosensitive nanohydrogels with antibacterial and anti-inflammatory properties for healing wounds infected with Staphylococcus aureus.

Life sciences·2024
Same author

Osteosarcoma PDX-Derived Cell Line Models for Preclinical Drug Evaluation Demonstrate Metastasis Inhibition by Dinaciclib through a Genome-Targeted Approach.

Clinical cancer research : an official journal of the American Association for Cancer Research·2023

Related Experiment Video

Updated: Nov 23, 2025

Candidate Gene Testing in Clinical Cohort Studies with Multiplexed Genotyping and Mass Spectrometry
05:53

Candidate Gene Testing in Clinical Cohort Studies with Multiplexed Genotyping and Mass Spectrometry

Published on: June 21, 2018

10.4K

[Gene polymorphism in oral lichen planus].

Ying-Xiao Pan1, Da-Wei Guo1, Xin Li1

  • 1Dept. of Stomatology, Qingdao University & Dept. of Stomatology, Affiliated Qingdao Municipal Hospital, Qingdao University, Qigndao 266000, China.

Hua Xi Kou Qiang Yi Xue Za Zhi = Huaxi Kouqiang Yixue Zazhi = West China Journal of Stomatology
|December 30, 2020
PubMed
Summary
This summary is machine-generated.

Oral lichen planus (OLP), a common oral mucosa inflammation, may be linked to genetic variations. This review examines gene polymorphisms in tumor necrosis factor, interferon, and interleukin families related to OLP.

Keywords:
etiologygene polymorphismgeneticsoral lichen planus

More Related Videos

Author Spotlight: Unlocking the Mysteries of Oral Potential Malignancies
05:42

Author Spotlight: Unlocking the Mysteries of Oral Potential Malignancies

Published on: August 11, 2023

1.4K
High-resolution Melting PCR for Complement Receptor 1 Length Polymorphism Genotyping: An Innovative Tool for Alzheimer's Disease Gene Susceptibility Assessment
07:26

High-resolution Melting PCR for Complement Receptor 1 Length Polymorphism Genotyping: An Innovative Tool for Alzheimer's Disease Gene Susceptibility Assessment

Published on: July 18, 2017

12.1K

Related Experiment Videos

Last Updated: Nov 23, 2025

Candidate Gene Testing in Clinical Cohort Studies with Multiplexed Genotyping and Mass Spectrometry
05:53

Candidate Gene Testing in Clinical Cohort Studies with Multiplexed Genotyping and Mass Spectrometry

Published on: June 21, 2018

10.4K
Author Spotlight: Unlocking the Mysteries of Oral Potential Malignancies
05:42

Author Spotlight: Unlocking the Mysteries of Oral Potential Malignancies

Published on: August 11, 2023

1.4K
High-resolution Melting PCR for Complement Receptor 1 Length Polymorphism Genotyping: An Innovative Tool for Alzheimer's Disease Gene Susceptibility Assessment
07:26

High-resolution Melting PCR for Complement Receptor 1 Length Polymorphism Genotyping: An Innovative Tool for Alzheimer's Disease Gene Susceptibility Assessment

Published on: July 18, 2017

12.1K

Area of Science:

  • Immunodermatology
  • Oral Medicine
  • Genetics

Background:

  • Oral lichen planus (OLP) is a prevalent chronic inflammatory condition affecting the oral mucosa, with an estimated adult prevalence of 0.5%-2%.
  • The precise causes and mechanisms underlying OLP development remain incompletely understood.
  • Emerging evidence suggests a potential role for genetic variations in the pathogenesis of OLP.

Purpose of the Study:

  • To comprehensively review existing research on the association between gene polymorphism and oral lichen planus.
  • To consolidate findings on specific gene families implicated in OLP susceptibility and development.

Main Methods:

  • Systematic literature search for studies investigating gene polymorphism in oral lichen planus.
  • Analysis and synthesis of data from selected studies focusing on candidate genes and their variants.
  • Categorization of reviewed genes into relevant families such as tumor necrosis factor, interferon, and interleukin.

Main Results:

  • Several gene families, including tumor necrosis factor (TNF), interferon (IFN), and interleukin (IL) genes, have been extensively studied in relation to OLP.
  • Specific polymorphisms within these gene families have shown associations with OLP risk and clinical presentation in various populations.
  • Enzyme and receptor gene families also represent areas of investigation for their potential contribution to OLP pathogenesis.

Conclusions:

  • Genetic polymorphism is a significant factor potentially contributing to the pathogenesis of oral lichen planus.
  • Further research into specific genetic variations within TNF, IFN, IL, enzyme, and receptor families is warranted to elucidate OLP etiology.
  • Understanding these genetic links may pave the way for novel diagnostic and therapeutic strategies for OLP.