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Updated: Nov 23, 2025

Modeling the Endothelial Glycocalyx Post-Pneumonectomy in a 3D Fluidic Chip - An Approach to Fabricating a Vascular-based Organ-on-Chip System

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Published on: September 16, 2025

Vascularized Organoids: A More Complete Model.

¹Department of Oncology, Affiliated Zhongshan Hospital of Dalian University, Dalian, China.

International Journal of Stem Cells

|December 30, 2020

Summary

This summary is machine-generated.

Vascularized organoids, created by co-culturing stem cells with endothelial cells, overcome limitations in current organoid models. This advancement enhances their reliability for stem cell research and clinical applications.

Keywords:

Applications Pluripotent stem cells Translational medicine Vascular organoids

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Published on: April 18, 2025

Area of Science:

Biomedical Engineering
Stem Cell Biology
Regenerative Medicine

Background:

Organoids are emerging in vitro models with potential for personalized therapy.
Current organoids lack essential stromal components like blood vessels, limiting their ex vivo application.
Vascularization is a critical unmet need for functional organoid development.

Purpose of the Study:

To summarize the progress, applications, and future prospects of vascularized organoids.
To highlight the development of organoids with integrated vascular networks.
To address the limitations of current organoid models in mimicking in vivo complexity.

Main Methods:

Co-culturing pluripotent stem cells, mesenchymal stem cells, and endothelial cells.
Utilizing 3D substrate matrices for organoid construction.
Focusing on the integration of vascular networks within organoid structures.

Main Results:

Successful construction of novel organoid models with vascularization.
Demonstration of enhanced morphological and functional recapitulation compared to avascular organoids.
Improved reliability of organoids for stem cell research and clinical applications.

Conclusions:

Vascularized organoids represent a significant advancement over traditional organoid models.
The integration of vascular networks is crucial for developing more functional and reliable organoids.
Vascularized organoids hold great promise for future stem cell research and precision medicine.