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Current treatments for atopic dermatitis in Japan
Kyohei Miyano1,2, Yuichiro Tsunemi1
1Department of Dermatology, Saitama Medical University, Saitama, Japan.
The Journal of Dermatology
|December 30, 2020
Summary
Effective atopic dermatitis treatment focuses on symptom control and daily function. For moderate to severe cases, systemic therapies like dupilumab are crucial alongside topical treatments to maintain remission.
Area of Science:
- Dermatology
- Immunology
- Pharmacology
Background:
- Atopic dermatitis treatment aims for symptom control and minimal daily impact.
- Topical therapies (corticosteroids, tacrolimus, delgocitinib) form the basis of treatment.
- Proactive therapy is used for maintenance after remission induction.
Purpose of the Study:
- To present a treatment algorithm for atopic dermatitis.
- To emphasize maintaining remission after induction.
- To summarize current medication therapies in Japan.
Main Methods:
- Review of current topical and systemic therapies for atopic dermatitis.
- Analysis of treatment strategies for moderate to severe cases.
- Focus on dupilumab's advantages in specific patient populations.
Main Results:
- Topical therapies are insufficient for moderate to severe atopic dermatitis.
- Systemic therapies (cyclosporin, UV, dupilumab) are necessary in combination.
- Dupilumab shows high efficacy, safety, and ease of use, especially in elderly patients.
Conclusions:
- A comprehensive treatment algorithm is needed for atopic dermatitis.
- Maintaining remission is as critical as inducing it.
- Current Japanese medication therapies are summarized, highlighting dupilumab's role.
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