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Updated: Nov 23, 2025

Author Spotlight: Regenerative Peripheral Nerve Interface (RPNI) Surgery in Postamputation Pain Management
Published on: March 15, 2024
Functional Limb Restoration Through Amputation: Minimizing Pain and Optimizing Function With the Use of Advanced
Jason M Souza1, Sean M Wade2, Colin J Harrington2
1Department of Surgery, Division of Plastic and Reconstructive Surgery, Uniformed Services University - Walter Reed National Military Medical Center Surgery, Bethesda, Maryland.
Advanced orthoplastic techniques transform elective amputation into a restorative procedure. This case study shows improved function and reduced pain in a soldier after transtibial amputation, enabling return to active duty.
Area of Science:
- Orthoplastic surgery
- Reconstructive surgery
- Trauma surgery
Background:
- Amputation is increasingly considered for complex extremity trauma.
- Reconstructive techniques used in limb salvage are underutilized in amputation surgery.
- Orthoplastic techniques offer potential for improved amputation outcomes.
Observation:
- A soldier with a proximal tibial defect elected amputation after failed limb salvage.
- The patient had tibial allodynia and limited ankle function.
- Orthoplastic techniques were applied during transtibial amputation.
Findings:
- A free fasciocutaneous flap provided soft tissue coverage.
- A pedicled vascularized fibula addressed the tibial defect.
- Myoneural interface and nerve constructs improved function and reduced pain.
Implications:
- Orthoplastic amputation surgery can optimize pain and function.
- This approach maximizes the rehabilitative potential for amputees.
- Advanced techniques enable amputation as a restorative procedure.
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