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Blunted Muscle Mitochondrial Responses to Exercise Training in Older Adults With HIV
Catherine M Jankowski1, Melissa P Wilson2,3, Samantha MaWhinney2
1College of Nursing, University of Colorado Anschutz Medical Campus, Aurora, Colorado, USA.
Background:
Muscle mitochondrial dysfunction associated with HIV and antiretroviral therapy (ART) may improve with exercise.
Methods:
Muscle specimens obtained before and after 24 weeks of exercise in older people with HIV (PWH; n = 18; ART >2 years) and uninfected controls (n = 21) were analyzed for citrate synthase (CS) activity and complexes (C) I-V, manganese superoxide dismutase (MnSOD), peroxisome proliferator-activated receptor-γ coactivator-1 (PGC1α), and voltage-dependent anion channel 1 (VDAC1) content.
Results:
Only controls had increased CS, MnSOD, PGC1α, and CIV (P ≤ .01; P < .01 vs PWH) after training.
Conclusions:
The blunted mitochondrial adaptations to training in PWH suggests the need for different types of exercise-induced stimulation.
Clinical Trials Registration:
NCT02404792.
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