Therapeutic approaches against coronaviruses acute respiratory syndrome

Area of Science:

• Virology
• Infectious Diseases
• Drug Discovery

Background:

• Human coronaviruses have caused major epidemics and a pandemic, posing a global health threat.
• Currently, no specific drugs are approved for treating or preventing human coronavirus infections.
• Several existing and experimental agents exhibit antiviral activity against coronaviruses in laboratory and animal studies.

Purpose of the Study:

• To review the virology of human coronaviruses and identify key biological targets.
• To summarize current therapeutic strategies for inhibiting coronavirus infections.
• To highlight FDA-approved and preclinical drugs targeting conserved viral elements.

Main Methods:

• Literature review of scientific articles on coronavirus virology and therapeutics.
• Analysis of in vitro and in vivo studies on antiviral agents.
• Focus on drugs targeting conserved viral elements essential for coronavirus replication.

Main Results:

• Identification of key biological targets within human coronaviruses.
• Summary of promising antiviral agents, including FDA-approved and preclinical candidates.
• Highlighting drugs that target conserved viral elements for broad-spectrum activity.

Conclusions:

• Several therapeutic agents show potential for combating coronavirus infections.
• Targeting conserved viral elements offers a promising strategy for developing new treatments.
• Further research and clinical trials are needed to validate these therapeutic options.