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Bilateral brain dysfunction during motor activation in type II schizophrenia measured by EEG mapping
W Guenther1, P Davous, J L Godet
1Psychiatric University Hospital LDI, Munich, F.R.G.
Biological Psychiatry
|February 1, 1988
Summary
Schizophrenia patients with negative symptoms show bilateral brain dysfunction, unlike those with positive symptoms who exhibit left hemisphere issues. This suggests distinct neurological patterns for different schizophrenia presentations.
Area of Science:
- Neuroscience
- Psychiatry
- Neuroimaging
Background:
- Neuroleptic treatment in schizophrenia can lead to motor dysfunction.
- Previous studies suggested left hemisphere dysfunction in Type I schizophrenia patients.
- Negative symptoms in schizophrenia are associated with distinct neurophysiological patterns.
Purpose of the Study:
- To investigate electroencephalographic (EEG) mapping in neuroleptic-treated schizophrenic patients with marked negative symptomatology (Type II).
- To compare EEG findings between Type II patients and previously studied Type I patients.
- To explore the relationship between brain dysfunction patterns and schizophrenia symptom dimensions.
Main Methods:
- EEG mapping was performed on 10 right-handed Type II schizophrenic patients during simple and multisensorimotor tasks.
- Cortical activation was assessed across different frequency bands, referred to resting states.
- Data were compared with previous findings from Type I patients and other neuroimaging studies.
Main Results:
- Type II patients showed minor increases in delta and theta power at rest.
- During motor tasks, Type II patients exhibited bilateral brain dysfunction, characterized by nonreactivity in most bands and alpha hyperreactivity.
- This contrasts with Type I patients, who showed signs of left hemisphere dysfunction and right hemisphere overactivation.
Conclusions:
- Marked bilateral brain dysfunction in Type II schizophrenia may correlate with the negative symptom pole.
- Left hemisphere dysfunction and compensatory overactivation appear linked to positive symptomatology.
- Potential "uncoupling" between electrical and circulatory brain parameters may exist in schizophrenia, differing between Type I and Type II patients.
