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Patients With cT1N0M0 Oral Squamous Cell Carcinoma Benefit From Elective Neck Dissection: A SEER-Based Study
Alimujiang Wushou1, Meng Wang1, Feiluore Yibulayin2
11Department of Oral and Maxillofacial Surgery and Oral Biomedical Engineering Laboratory, Shanghai Stomatological Hospital, Fudan University.
Journal of the National Comprehensive Cancer Network : JNCCN
|December 30, 2020
Summary
Elective neck dissection (END) significantly improves survival for early-stage oral squamous cell carcinoma (OSCC) patients. This procedure offers a survival benefit for cT1N0M0 OSCC, alongside factors like younger age and lower pathologic grade.
Area of Science:
- Oncology
- Surgical Oncology
- Head and Neck Cancer Research
Background:
- Oral squamous cell carcinoma (OSCC) incidence is rising globally.
- Surgery is standard for early OSCC, but elective neck dissection (END) value is unclear for small tumors.
- Limited evidence exists for END's benefit in early-stage OSCC.
Purpose of the Study:
- Identify survival predictors for clinical stage T1N0M0 (cT1N0M0) OSCC.
- Determine if upfront END improves survival in these patients.
- Analyze prognostic factors influencing outcomes in early OSCC.
Main Methods:
- Retrieved data from the SEER database for cT1N0M0 OSCC patients.
- Utilized Kaplan-Meier analysis for overall and disease-specific survival.
- Employed Cox regression for prognostic factor determination.
Main Results:
- Analyzed 5,752 patients; 38.1% had END, 61.9% did not.
- Advanced age and high pathologic grade predicted poorer survival.
- Married status and END were independent positive prognostic factors (HR 0.708, P<.001 for END).
Conclusions:
- Patients with cT1N0M0 OSCC benefit significantly from END.
- END improves both overall and disease-specific survival.
- Upfront END is a positive prognostic factor for early-stage OSCC.
