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Updated: Nov 23, 2025

Induction of Invasive Transitional Cell Bladder Carcinoma in Immune Intact Human MUC1 Transgenic Mice: A Model for Immunotherapy Development
Published on: October 30, 2013
[Advance in immunotherapy on biliary tract cancers]
L G Liu1, Y J Zhang1, X A Wang1
1Department of Biliary-Pancreatic Surgery,Renji Hospital Affiliated to Shanghai Jiao Tong University School of Medicine;Shanghai Key Laboratory of Biliary Tract Disease Research; Shanghai Research Center of Biliary Tract Disease; State Key Laboratory for Oncogenes and Related Genes,Shanghai 200127,China.
Abstract:
Biliary tract cancers(BTC),including gallbladder cancer and cholangiocarcinoma,has the characteristics of low early diagnosis rate,complex anatomy,insensitivity to radiotherapy and chemotherapy, and poor prognosis.In recent years,immunotherapy as a new method,has made great progress in the treatment of advanced malignant tumors.Immunotherapy is gradually applied in the treatment of BTC,such as inhibitory agents targeting the immune checkpoint receptor pathway,adoptive immunotherapy and tumor vaccines.
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