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Updated: Nov 23, 2025

Digital Spatial Profiling for Characterization of the Microenvironment in Adult-Type Diffusely Infiltrating Glioma
Published on: September 13, 2022
Existence of traveling wave solutions to data-driven glioblastoma multiforme growth models with density-dependent
Ardak Kashkynbayev1, Yerlan Amanbek1, Bibinur Shupeyeva1
1Department of Mathematics, Nazarbayev University, 010000 Nur-Sultan, Kazakhstan.
Abstract:
Mathematical modeling for cancerous disease has attracted increasing attention from the researchers around the world. Being an effective tool, it helps to describe the processes that happen to the tumour as the diverse treatment scenarios. In this paper, a density-dependent reaction-diffusion equation is applied to the most aggressive type of brain cancer, Glioblastoma multiforme. The model contains the terms responsible for the growth, migration and proliferation of the malignant tumour. The traveling wave solution used is justified by stability analysis. Numerical simulation of the model is provided and the results are compared with the experimental data obtained from the reference papers.

