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Updated: Nov 23, 2025

The Use of Chemostats in Microbial Systems Biology
Published on: October 14, 2013
Study of the chemostat model with non-monotonic growth under random disturbances on the removal rate
Tomás Caraballo1, Renato Colucci2, Javier López-de-la-Cruz1
1Departamento de Ecuaciones Diferenciales y Análisis Numérico, C/Tarfia s/n, Facultad de Matemáticas, Universidad de Sevilla, 41012 Sevilla, Spain.
Abstract:
We revisit the chemostat model with Haldane growth function, here subject to bounded random disturbances on the input flow rate, as often met in biotechnological or waste-water industry. We prove existence and uniqueness of global positive solution of the random dynamics and existence of absorbing and attracting sets that are independent of the realizations of the noise. We study the long-time behavior of the random dynamics in terms of attracting sets, and provide first conditions under which biomass extinction cannot be avoided. We prove conditions for weak and strong persistence of the microbial species and provide lower bounds for the biomass concentration, as a relevant information for practitioners. The theoretical results are illustrated with numerical simulations.
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