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Inducement and Evaluation of a Murine Model of Experimental Myopia
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Pharmacotherapeutic candidates for myopia: A review

Wen-Yi Wang1, Camille Chen1, Justine Chang1

  • 1Department of Ophthalmology, National Taiwan University Hospital, Taipei, Taiwan.

Biomedicine & Pharmacotherapy = Biomedecine & Pharmacotherapie
|December 31, 2020
PubMed

Insights

Environmental factors significantly influence myopia development. Dopamine receptor pathways and atropine treatments show promise for myopia control, with ongoing research focusing on optimizing efficacy and safety.

Area of Science:

  • Ophthalmology
  • Molecular Biology
  • Genetics

Background:

  • Myopia (nearsightedness) pathogenesis involves complex genetic and environmental interactions.
  • Environmental factors are increasingly recognized as major drivers of myopia prevalence and severity.
  • Understanding the molecular mechanisms of eye development is crucial for myopia intervention.

Purpose of the Study:

  • To review the mechanisms underlying myopia pathogenesis.
  • To identify potential clinical intervention targets for myopia.
  • To discuss current and future pharmacotherapeutic strategies for myopia control.

Main Methods:

  • Review of recent scientific literature on myopia.
  • Analysis of studies on animal models of myopia.
  • Examination of signaling pathways involved in eye development and myopia.

Main Results:

  • Environmental factors play a more significant role than genetic factors in myopia.
  • Dopamine receptor signaling is a key pathway in myopia regulation.
  • Atropine treatment demonstrates efficacy in controlling myopia progression.

Conclusions:

  • Pharmacotherapeutics targeting environmentally induced changes are key for myopia management.
  • Optimizing atropine efficacy and safety is an ongoing research focus.
  • Combinatorial therapies (e.g., low-dose atropine with contact lenses/orthokeratology) warrant further investigation.
Keywords:
AtropineAxial growthDopamineMyopiaPharmaceutical interventionSclera

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