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lncRNA - Long Non-coding RNAs02:39

lncRNA - Long Non-coding RNAs

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In humans, more than 80% of the genome gets transcribed. However, only around 2% of the genome codes for proteins. The remaining part produces non-coding RNAs which includes ribosomal RNAs, transfer RNAs, telomerase RNAs, and regulatory RNAs, among other types. A large number of regulatory non-coding RNAs have been classified into two groups depending upon their length – small non-coding RNAs, such as microRNA, which are less than 200 nucleotides in length, and long non-coding RNA...
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As the name suggests, non-LTR retrotransposons lack the long terminal repeats characteristic of the LTR retrotransposons. Additionally, both LTR and non-LTR retrotransposons use distinct mechanisms of mobilization. Non-LTR retrotransposons are further divided into two classes - Long interspersed nuclear elements (LINEs) and short interspersed nuclear elements (SINEs), both of which occur abundantly in most mammals, including humans. Some of the active non-LTR retrotransposons in humans are L1...
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Lymphoid cells and tissues are integral to the immune system, which is crucial in maintaining our body's defense against harmful pathogens. They form the building blocks of lymphoid organs, which include the spleen, thymus, and lymph nodes.
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Three main types of RNA are involved in protein synthesis: messenger RNA (mRNA), transfer RNA (tRNA), and ribosomal RNA (rRNA). These RNAs perform diverse functions and can be broadly classified as protein-coding or non-coding RNA. Non-coding RNAs play important roles in regulating gene expression in response to developmental and environmental changes. Non-coding RNAs in prokaryotes can be manipulated to develop more effective antibacterial drugs for human or animal use.
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Ribosome synthesis is a highly complex and coordinated process involving more than 200 assembly factors. The synthesis and processing of ribosomal components occurs not only in the nucleolus but also in the nucleoplasm and the cytoplasm of eukaryotic cells.
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Long Non-Coding RNAs in Diffuse Large B-Cell Lymphoma.

Kasper Thystrup Karstensen1, Aleks Schein1, Andreas Petri1

  • 1Center for RNA Medicine, Department of Clinical Medicine, Aalborg University, DK-2450 Copenhagen, Denmark.

Non-Coding RNA
|December 31, 2020
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Summary
This summary is machine-generated.

Long non-coding RNAs (lncRNAs) play a role in Diffuse large B-cell lymphoma (DLBCL) development. This review explores lncRNAs in DLBCL pathogenesis and provides molecular signatures for future research.

Keywords:
DLBCLlncRNAmiRNArituximab

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Area of Science:

  • Oncology
  • Molecular Biology
  • Genetics

Background:

  • Diffuse large B-cell lymphoma (DLBCL) is the most common adult lymphoid malignancy.
  • Despite treatment advances, 30-40% of DLBCL patients experience relapse or refractory disease, necessitating novel therapeutic strategies.
  • Long non-coding RNAs (lncRNAs) are emerging as critical regulators in various human diseases, including cancer.

Purpose of the Study:

  • To review the current understanding of lncRNAs in the pathogenesis and progression of DLBCL.
  • To provide a comprehensive overview of the role of lncRNAs in DLBCL.
  • To offer molecular signatures of lncRNAs in DLBCL cell lines to facilitate future research.

Main Methods:

  • Literature review of lncRNAs in DLBCL.
  • Analysis of molecular signatures of lncRNAs in DLBCL cell lines.

Main Results:

  • lncRNAs are implicated in the pathogenesis and progression of DLBCL.
  • Current knowledge of lncRNAs in DLBCL is limited but growing.
  • Molecular signatures for lncRNAs in DLBCL cell lines have been identified.

Conclusions:

  • lncRNAs represent a promising area for understanding and potentially treating DLBCL.
  • Further research into lncRNAs is crucial for developing new therapeutic strategies for DLBCL patients.
  • The provided molecular signatures can serve as a foundation for future investigations into lncRNA functions in DLBCL.