Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Overview of Microscopy Techniques01:22

Overview of Microscopy Techniques

14.2K
The early pioneers of microscopy opened a window into the invisible world of microorganisms. In 1830, Joseph Jackson Lister created an essentially modern light microscope. The 20th century saw the development of microscopes that leveraged nonvisible light, such as fluorescence microscopy that uses an ultraviolet light source and electron microscopy that uses short-wavelength electron beams. These advances significantly improved magnification, image resolution, and contrast. By comparison, the...
14.2K
Atomic Force Microscopy01:08

Atomic Force Microscopy

3.8K
Atomic force microscopy (AFM) is a type of scanning probe microscopy that can analyze topographic details of various specimens like ceramics, glass, polymers, and biological samples. AFM offers over 1000 times more resolution than the optical imaging system. Images generated from AFM are three-dimensional surface profiles, offering an advantage over the flat, two-dimensional images from other imaging techniques.
The AFM Probe
The probe is regarded as the heart of any AFM setup and comprises the...
3.8K
Proteomics01:33

Proteomics

8.9K
A proteome is the entire set of proteins that a cell type produces. We can study proteomes using the knowledge of genomes because genes code for mRNAs, and the mRNAs encode proteins. Although mRNA analysis is a step in the right direction, not all mRNAs are translated into proteins.
Proteomics is the study of proteomes' function. It involves the large-scale systematic study of the proteome to denote the protein complement expressed by a genome. Scientist Mark Wilkins coined the term...
8.9K
DNA Microarrays02:34

DNA Microarrays

19.8K
Microarrays are high-throughput and relatively inexpensive assays that can be automated to analyze large quantities of data at a time. They are used in genome-wide studies to compare gene or protein expression under two varied conditions, such as healthy and diseased states. Microarrays consist of glass or silica slides on which probe molecules are covalently attached through surface functionalization. Most commonly, the slides are prepared through the chemisorption of silanes to silica...
19.8K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

ThASR4 enhances salt tolerance in transgenic Tamarix and Arabidopsis by scavenging reactive oxygen species.

BMC plant biology·2026
Same author

Chinese expert consensus on conversion and perioperative therapy of primary liver cancer (2024 edition).

Hepatobiliary surgery and nutrition·2026
Same author

Global, regional, and national burden of early-onset and late-onset colorectal cancer, 1990-2021: a comparative analysis for the Global Burden of Disease Study 2021.

Future science OA·2026
Same author

Effect of Nutritional Intervention on the Milk Fat Globule Membrane Proteome of Colostrum From Lactating Yaks.

Proteomics·2026
Same author

Biomimetic hybrid nanoparticles for dual regulation of macrophage pyroptosis and metabolism in rheumatoid arthritis.

Journal of nanobiotechnology·2026
Same author

Prussian Blue Analogues with Entropically Stabilized Coordination Environment for High-Energy and Long-Life Aqueous Potassium-Ion Batteries.

Journal of the American Chemical Society·2026
Same journal

A compact low-power magnetic particle imaging scanner based on a permanent-magnet field-free-line generator with high gradient.

The Review of scientific instruments·2026
Same journal

Achieving ultrahigh resolution with high efficiency: Optical design of the two-dimensional Resonant Inelastic X-ray Scattering (2D-RIXS) spectrometer at NanoTerasu beamline 02U.

The Review of scientific instruments·2026
Same journal

Automated laboratory x-ray diffractometer and fluorescence spectrometer for high-throughput materials characterization.

The Review of scientific instruments·2026
Same journal

Nonlinear Bayesian Doppler tomography for simultaneous reconstruction of flow and temperature.

The Review of scientific instruments·2026
Same journal

A Reflectance-based multimodal wearable photoplethysmography (PPG) sensor.

The Review of scientific instruments·2026
Same journal

Temporal analysis of products-Raman (TAP-Raman): An integrated setup for operando spectroscopy and transient kinetic analysis.

The Review of scientific instruments·2026
See all related articles

Related Experiment Video

Updated: Nov 23, 2025

Author Spotlight: Introduction to Active Probe Atomic Force Microscopy with Quattro-Parallel Cantilever Arrays
05:04

Author Spotlight: Introduction to Active Probe Atomic Force Microscopy with Quattro-Parallel Cantilever Arrays

Published on: June 13, 2023

2.1K

Multiprobe scanning probe microscope using a probe-array head.

Fengming Sun1, Zhenyu Zhu2, Long Ma1

  • 1Sino-European Institute of Aviation Engineering, Civil Aviation University of China, Tianjin 300300, China.

The Review of Scientific Instruments
|December 31, 2020
PubMed
Summary
This summary is machine-generated.

A novel multiprobe scanning probe microscope (SPM) utilizes seven microelectromechanical system (MEMS) probes for enhanced imaging efficiency. This system employs a force feedback strategy and a large-range nano-measuring machine for advanced nanoscale measurements.

More Related Videos

An Experimental Protocol for Assessing the Performance of New Ultrasound Probes Based on CMUT Technology in Application to Brain Imaging
16:01

An Experimental Protocol for Assessing the Performance of New Ultrasound Probes Based on CMUT Technology in Application to Brain Imaging

Published on: September 24, 2017

10.7K
Co-localizing Kelvin Probe Force Microscopy with Other Microscopies and Spectroscopies: Selected Applications in Corrosion Characterization of Alloys
12:18

Co-localizing Kelvin Probe Force Microscopy with Other Microscopies and Spectroscopies: Selected Applications in Corrosion Characterization of Alloys

Published on: June 27, 2022

3.1K

Related Experiment Videos

Last Updated: Nov 23, 2025

Author Spotlight: Introduction to Active Probe Atomic Force Microscopy with Quattro-Parallel Cantilever Arrays
05:04

Author Spotlight: Introduction to Active Probe Atomic Force Microscopy with Quattro-Parallel Cantilever Arrays

Published on: June 13, 2023

2.1K
An Experimental Protocol for Assessing the Performance of New Ultrasound Probes Based on CMUT Technology in Application to Brain Imaging
16:01

An Experimental Protocol for Assessing the Performance of New Ultrasound Probes Based on CMUT Technology in Application to Brain Imaging

Published on: September 24, 2017

10.7K
Co-localizing Kelvin Probe Force Microscopy with Other Microscopies and Spectroscopies: Selected Applications in Corrosion Characterization of Alloys
12:18

Co-localizing Kelvin Probe Force Microscopy with Other Microscopies and Spectroscopies: Selected Applications in Corrosion Characterization of Alloys

Published on: June 27, 2022

3.1K

Area of Science:

  • Nanotechnology
  • Microelectromechanical Systems (MEMS)
  • Scanning Probe Microscopy (SPM)

Background:

  • Traditional scanning probe microscopes often face limitations in imaging speed and efficiency.
  • Developing multiprobe systems is crucial for accelerating nanoscale surface characterization.

Purpose of the Study:

  • To introduce a novel microelectromechanical system (MEMS)-based multiprobe scanning probe microscope (SPM) designed for improved imaging efficiency.
  • To demonstrate the capability of the multiprobe SPM for high-resolution nanoscale measurements.

Main Methods:

  • Development of an SPM head integrating seven identical MEMS probes, each with displacement sensors and Z-axis actuators.
  • Implementation of a force constant mode based on a force feedback strategy.
  • Integration of a nano-measuring machine with lateral XY scanners offering a 25 mm × 25 mm motion range.

Main Results:

  • Successful calibration and measurement of a one-dimensional grating using the multiprobe SPM.
  • Demonstration of the system's capability for efficient multiprobe scanning.

Conclusions:

  • The developed MEMS-based multiprobe SPM offers a promising approach to enhance imaging efficiency in nanoscale surface analysis.
  • The system's design and demonstrated performance pave the way for advanced applications in materials science and nanotechnology.