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Interplay of COVID-19 and physiological dysfunctions

Yu-Hsiu Chang1, Chih-Heng Huang1, Po-Shiuan Hsieh2

  • 1Institute of Preventive Medicine, National Defense Medical Center, New Taipei City, Taiwan.

The Chinese Journal of Physiology
|December 31, 2020
PubMed

Insights

This study explores how severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2) causes physiological and immunological dysfunction. It links COVID-19 to immune injury, multiorgan damage, and disease progression, especially in patients with comorbidities.

Area of Science:

  • Immunology
  • Pathophysiology
  • Infectious Diseases

Background:

  • The COVID-19 pandemic significantly impacts global health and socioeconomic structures.
  • Understanding SARS-CoV-2 pathophysiology is crucial for managing the ongoing crisis.
  • There is a growing need to comprehend the clinical implications of SARS-CoV-2 infection.

Purpose of the Study:

  • To delineate the role of COVID-19 in physiological and immunological dysfunction.
  • To highlight mechanisms and effects of SARS-CoV-2 on major organ systems.
  • To analyze the contribution of SARS-CoV-2 infection to multiorgan system failure.

Main Methods:

  • Review and analysis of existing studies on COVID-19.
  • Examination of statistical data concerning comorbidities in COVID-19 patients.
  • Inference on the linkage between COVID-19, immune injury, and organ damage.

Main Results:

  • COVID-19 can lead to significant physiological and immunological dysfunction.
  • SARS-CoV-2 infection affects multiple major organ systems.
  • Comorbidities may exacerbate COVID-19-related multiorgan damage and disease progression.

Conclusions:

  • SARS-CoV-2 infection is associated with immune injury and multiorgan system damage.
  • Understanding these mechanisms is vital for predicting and managing COVID-19 severity.
  • Further research is needed to fully elucidate the long-term consequences of COVID-19 on organ systems.

Keywords:
COVID-19Physiological dysfunctionSARS-CoV-2

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