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Phytoglycogen Nanoparticle Delivery System for Inorganic Selenium Reduces Cytotoxicity without Impairing Selenium
Tamiru N Alkie1, Jondavid de Jong1,2, Emily Moore2
1Department of Health Sciences, Wilfrid Laurier University, Waterloo, ON N2L 3C5, Canada.
International Journal of Nanomedicine
|December 31, 2020
Summary
Nanoparticle delivery systems (SeNPs) reduce the toxicity of inorganic selenium (Na2SeO3) in animal cells. SeNPs maintain selenium bioavailability, offering a safer method for animal dietary supplementation.
Area of Science:
- Animal Nutrition
- Trace Elements
- Nanotechnology
Background:
- Selenium is vital for animal health, acting as an antioxidant.
- Inorganic selenium (Na2SeO3) is cost-effective but cytotoxic.
- Nanoparticle delivery systems (SeNPs) can mitigate selenium's toxicity.
Purpose of the Study:
- To evaluate the efficacy of SeNPs in reducing inorganic selenium cytotoxicity.
- To compare selenium bioavailability from soluble Na2SeO3 versus SeNPs.
- To assess SeNP safety in various animal cell types.
Main Methods:
- Rainbow trout and bovine cells were treated with soluble Na2SeO3 or two SeNP formulations (ionic and covalent).
- Cytotoxicity and selenium bioavailability (GPx activity and gene expression) were measured.
Main Results:
- SeNPs significantly reduced selenium-induced cytotoxicity across all cell types.
- Selenium bioavailability was comparable between soluble Na2SeO3 and SeNPs.
- GPx activity and GPx1 transcript levels were similarly elevated for both delivery methods.
Conclusions:
- SeNPs enable safe inorganic selenium delivery, maintaining bioavailability.
- This approach allows for higher, typically toxic, selenium doses in animal diets.
- Nanoparticle-assisted selenium supplementation holds promise for animal health.
