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Polymalic Acid-based Nano Biopolymers for Targeting of Multiple Tumor Markers: An Opportunity for Personalized Medicine?
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Targeting BRD9 for Cancer Treatment: A New Strategy

Xiuzuo Zhu1, Yi Liao2, Liling Tang1

  • 1Key Laboratory for Biorheological Science and Technology of Ministry of Education, College of Bioengineering, Chongqing University, Chongqing, People's Republic of China.

Oncotargets and Therapy
|December 31, 2020
PubMed

Insights

Bromodomain-containing protein 9 (BRD9) drives cancer growth through epigenetic modifications. Targeting BRD9 offers therapeutic potential, but its precise biological roles require further investigation for effective cancer treatment strategies.

Area of Science:

  • Oncology
  • Epigenetics
  • Molecular Biology

Background:

  • Bromodomain-containing protein 9 (BRD9) is a subunit of the non-canonical barrier-to-autointegration factor (ncBAF) complex.
  • BRD9 is implicated in the oncogenesis of various cancer types by regulating tumor cell proliferation.

Purpose of the Study:

  • To review the mechanisms of BRD9 in carcinogenesis.
  • To summarize emerging strategies for targeting BRD9 in cancer therapeutics.

Main Methods:

  • Literature review of studies on BRD9 function in cancer.
  • Analysis of BRD9's role in epigenetic modification and gene transcription.

Main Results:

  • BRD9's oncogenic activity stems from its bromodomain, which mediates epigenetic modifications.
  • The bromodomain recruits the ncBAF complex to promoters, influencing gene transcription.

Conclusions:

  • Targeting BRD9 presents a promising avenue for cancer therapy.
  • Further research into BRD9's detailed biological mechanisms is crucial for its clinical application.
Keywords:
BRD9bromodomaincancerinhibitorncBAF

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