Related Experiment Video

Updated: Nov 23, 2025

Isolation, Characterization, and Purification of Macrophages from Tissues Affected by Obesity-related Inflammation
07:46

Isolation, Characterization, and Purification of Macrophages from Tissues Affected by Obesity-related Inflammation

Published on: April 3, 2017

25.7K

Functioning of Long Noncoding RNAs Expressed in Macrophage in the Development of Atherosclerosis

Xirui Ma1, Huifang Liu1, Fengling Chen1

  • 1Department of Endocrinology and Metabolism, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.

Frontiers in Pharmacology
|December 31, 2020
PubMed

Insights

Long noncoding RNAs (lncRNAs) regulate macrophage function in atherosclerosis. This review explores lncRNAs as potential biomarkers and therapeutic targets for atherosclerotic inflammation.

Area of Science:

  • Cardiovascular Biology
  • Molecular Biology
  • Immunology

Background:

  • Chronic inflammation is integral to atherosclerosis (AS) pathogenesis.
  • Monocytes/macrophages are key cellular players within atherosclerotic plaques.
  • Macrophage metabolism and plasticity are crucial in AS progression.

Purpose of the Study:

  • To review the role of long noncoding RNAs (lncRNAs) in macrophage biology.
  • To highlight the involvement of lncRNAs in atherosclerotic inflammation.
  • To identify lncRNAs as potential AS biomarkers and therapeutic targets.

Main Methods:

  • Comprehensive literature review of lncRNAs in macrophage biology and AS.
  • Analysis of recent findings on lncRNA regulation of macrophage metabolism and plasticity.
  • Synthesis of evidence linking lncRNAs to atherosclerotic inflammation.

Main Results:

  • lncRNAs significantly influence macrophage metabolism and plasticity.
  • Specific lncRNAs can either promote or suppress inflammation in AS.
  • Dysregulation of lncRNAs is implicated in AS development.

Conclusions:

  • lncRNAs represent critical regulators of macrophage function in AS.
  • Targeting lncRNAs offers potential for novel AS diagnostic biomarkers.
  • lncRNA-based therapies may provide future interventions for AS.
Keywords:
atherosclerosisfoam cell macrophagekappa Blong noncoding RNAmacrophage

More Related Videos

Using RNA-interference to Investigate the Innate Immune Response in Mouse Macrophages12:47

Using RNA-interference to Investigate the Innate Immune Response in Mouse Macrophages

Published on: November 3, 2014

11.9K
Quantification of Monocyte Transmigration and Foam Cell Formation from Individuals with Chronic Inflammatory Conditions09:41

Quantification of Monocyte Transmigration and Foam Cell Formation from Individuals with Chronic Inflammatory Conditions

Published on: October 17, 2017

13.6K

Related Concept Videos

Inflammation01:38

Inflammation

Overview
57.9K
lncRNA - Long Non-coding RNAs02:39

lncRNA - Long Non-coding RNAs

In humans, more than 80% of the genome gets transcribed. However, only around 2% of the genome codes for proteins. The remaining part produces non-coding RNAs which includes ribosomal RNAs, transfer RNAs, telomerase RNAs, and regulatory RNAs, among other types. A large number of regulatory non-coding RNAs have been classified into two groups depending upon their length – small non-coding RNAs, such as microRNA, which are less than 200 nucleotides in length, and long non-coding RNA...
9.4K
lncRNA - Long Non-coding RNAs02:39

lncRNA - Long Non-coding RNAs

3.1K
Atherosclerosis I: Introduction01:30

Atherosclerosis I: Introduction

Atherosclerosis is a progressive disorder characterized by the buildup of plaques on the arterial inner wall, causing them to narrow and harden over time. These plaques comprise lipids, calcium, blood components, carbohydrates, and fibrous tissue. The process primarily affects the intima of large and medium-sized arteries, reducing blood flow in any artery.Etiology and risk factorsThe cause of atherosclerosis is multifactorial, involving a complex interplay among endothelial injury, lipid...
412
Coronary Artery Disease II: Pathophysiology01:26

Coronary Artery Disease II: Pathophysiology

Coronary Artery Disease (CAD) originates from a series of events that impair the function of coronary arteries, the blood vessels responsible for delivering oxygen-rich blood to the heart muscle. The pathophysiology of CAD is closely linked to atherosclerosis, a chronic inflammatory and lipid-driven condition affecting the vascular endothelium.1. Endothelial DamageThe process begins with damage to the vascular endothelium, which serves as a protective barrier between the blood and the vessel...
196
MicroRNAs01:22

MicroRNAs

MicroRNA (miRNA) are short, regulatory RNA transcribed from introns—non-coding regions of a gene—or intergenic regions—stretches of DNA present between genes. Several processing steps are required to form biologically active, mature miRNA. The initial transcript, called primary miRNA (pri-mRNA), base-pairs with itself forming a stem-loop structure. Within the nucleus, an endonuclease enzyme, called Drosha, shortens the stem-loop structure into hairpin-shaped pre-miRNA. After...
23.3K