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Rapid Response in a Patient with Relapsed/Refractory Multiple Myeloma Treated with BRAF/MEK Inhibitors

Steve Biko Otieno1,2,3, Syed Nasir1,3, Alva Weir1,2

  • 1The University of Tennessee Health Science Center, Department of Hematology/Oncology, 19 S. Manassas, Memphis, TN 38103, USA.

Case Reports in Hematology
|December 31, 2020
PubMed

Insights

BRAFV600E mutations occur in 4-10% of multiple myeloma cases and may cause resistance to standard therapies. Targeted BRAF therapy in a relapsed/refractory patient showed 8.5 months of progression-free survival.

Area of Science:

  • Oncology
  • Molecular Biology
  • Genetics

Background:

  • Multiple myeloma is a hematologic malignancy with poor prognosis in relapsed/refractory cases.
  • The mitogen-activated protein kinase (MAPK) pathway is crucial in multiple myeloma pathogenesis.
  • BRAFV600E mutations activate the MAPK pathway, driving oncogenesis and potentially conferring resistance to proteasome inhibitors.

Observation:

  • This report details a patient with relapsed and refractory multiple myeloma harboring the BRAFV600E mutation.
  • BRAFV600E-directed therapy is not currently approved for multiple myeloma treatment.
  • The BRAFV600E mutation is found in 4-10% of multiple myeloma patients.

Findings:

  • The patient received BRAF-targeted therapy.
  • The patient achieved a progression-free survival (PFS) of 8.5 months.

Implications:

  • BRAF-targeted therapy shows potential in a subset of multiple myeloma patients with BRAFV600E mutations.
  • Further research is warranted to explore BRAF-directed therapies in multiple myeloma.
  • Understanding the role of BRAFV600E mutations may guide personalized treatment strategies for multiple myeloma.

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