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Acute Liver Rejection in a Multiple Myeloma Patient Treated with Lenalidomide
Iuliana Vaxman1,2,3, John Eaton4, Hee Eun Lee5
1Division of Hematology, Mayo Clinic, Rochester, MN, USA.
Abstract:
Herein we present a patient that underwent a liver transplant due to primary biliary cholangitis (PBC) and after 9 years developed multiple myeloma. Following the cessation of mycophenolate mofetil and 2 weeks after lenalidomide treatment was started, the patient experienced acute cellular rejection. The patient recovered after treatment with corticosteroids, resumption of mycophenolate mofetil, and cessation of lenalidomide. Lenalidomide-associated allograft rejection has been reported in other organs. However, this is the first case report of liver rejection induced by lenalidomide.
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