Related Experiment Video
Updated: Nov 23, 2025

Author Spotlight: Advancing Early Detection and Treatment of Gastrointestinal Tumors
Published on: February 16, 2024
EBV-Positive Gastric Cancer: Current Knowledge and Future Perspectives.
Keran Sun1, Keqi Jia2, Huifang Lv1
1Department of Oncology, The Affiliated Cancer Hospital of Zhengzhou University, Henan Cancer Hospital, Zhengzhou, China.
Epstein-Barr virus (EBV) causes a unique subset of gastric cancer. Immunotherapy shows high effectiveness for EBV-positive gastric cancer, offering a promising treatment avenue.
Area of Science:
- Oncology
- Virology
- Genetics
Background:
- Gastric cancer is a leading cause of cancer death globally.
- Epstein-Barr virus (EBV) is associated with a distinct subtype of gastric cancer.
- EBV-positive gastric cancer exhibits unique genomic features and a favorable prognosis.
Purpose of the Study:
- To review recent research on EBV-positive gastric cancer.
- To highlight the role of EBV in gastric carcinogenesis.
- To discuss the therapeutic potential of immunotherapy for EBV-positive gastric cancer.
Main Methods:
- Literature review of recent studies on EBV-positive gastric cancer.
- Analysis of the molecular mechanisms of EBV-induced gastric cancer.
- Evaluation of immunotherapy efficacy in EBV-positive gastric cancer patients.
Main Results:
- EBV integrates into the host genome, expressing latent proteins that alter DNA methylation via miRNA, leading to cancer development.
- EBV-positive gastric cancer is characterized by specific clinicopathological features.
- Immunotherapy demonstrates a high response rate in patients with EBV-positive gastric cancer.
Conclusions:
- Understanding EBV's role is crucial for diagnosing and treating gastric cancer.
- Immunotherapy represents a highly effective treatment strategy for EBV-positive gastric cancer.
- Further research can optimize clinical management and improve patient outcomes.
More Related Videos
Related Concept Videos
Barrett Esophagus-II: Clinical Manifestations and Management
To diagnose Barrett's esophagus, healthcare providers often recommend an endoscopy for those showing symptoms of acid reflux. The procedure...
Barrett Esophagus-I: Introduction
This constant acid exposure transforms the esophagus's pink mucosal lining (stratified squamous epithelium) into a type of lining more...
Cancer Vaccines
Cancer vaccines come in two categories: preventive (prophylactic) and treatment (active). Preventive vaccines, such as the Human Papillomavirus (HPV) vaccine, protect against viruses that cause certain...
Targeted Cancer Therapies
There are several types of targeted therapies against...
Gastroesophageal Reflux Disease II: Clinical Features and Management
Clinical Manifestations
GERD presents itself in a multitude of ways, with symptoms varying from person to person. The hallmark symptoms are...
Gastritis III: Clinical Manifestations and Management
Clinical manifestations of acute gastritis
The patient with acute gastritis may have a rapid onset of symptoms, such as epigastric pain or discomfort, dyspepsia, anorexia, hiccups, or nausea and vomiting, which can last from a few hours to a few days. Erosive or hemorrhagic gastritis may cause bleeding, which may manifest as blood in vomit or as...

