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Updated: Nov 23, 2025
Production and Administration of Therapeutic Mesenchymal Stem/Stromal Cell MSC Spheroids Primed in 3-D Cultures Under Xeno-free Conditions
Published on: March 18, 2017
GMP-Compatible, Xeno-Free Culture of Human Induced Mesenchymal Stem Cells
1The New York Stem Cell Foundation Research Institute, New York, NY, USA. gmdepeppo@nyscf.org.
Abstract:
Mesenchymal stem cells (MSCs) have been used in therapies owing to their regenerative potential, paracrine regulatory effects, and immunomodulatory activity. To foster commercialization and implementation of stem cells treatments, researchers have recently derived MSCs from human induced pluripotent stem cells (iMSCs). For therapeutic applications, human iMSCs must be produced in xeno-free culture conditions and following procedures that are compatible with the principles of Good Manufacturing Practice.
