Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Pharmacodynamics in Geriatric Patients: Effects of Age01:27

Pharmacodynamics in Geriatric Patients: Effects of Age

100
Age-related pharmacokinetic changes are extensively documented, but understanding age-related pharmacodynamic alterations is relatively limited. This knowledge gap can be partly attributed to the complexity of developing appropriate measures of drug responses compared to bioanalytical methods for determining drug concentrations.Most information regarding age-related differences in human pharmacodynamics originates from cross-sectional studies. However, these studies assume that observed mean...
100
Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Metabolism01:18

Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Metabolism

87
Geriatric patients show significant variation in how their bodies process medications, which can change how effective and safe treatments are. The liver is the primary organ where drug metabolism occurs, involving two main types of chemical reactions: phase I and II. Phase I metabolism is driven by the cytochrome P450 enzyme system, which includes key types such as CYP3A, CYP2D6, and CYP2C9. Research indicates that while aging doesn't notably alter the levels or activity of these enzymes, it...
87
Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Distribution01:00

Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Distribution

72
Drug distribution in the human body is influenced by several factors, including plasma protein concentration, body composition, blood flow, tissue-protein concentration, and tissue fluid pH. Among these, changes in plasma protein concentration and body composition due to aging significantly affect how drugs are distributed within the body. Specifically, aging is associated with a decrease in albumin levels by about 10% and an increase in α1-acid glycoprotein levels. These alterations are...
72
Drug Dosing: Geriatric Patients01:15

Drug Dosing: Geriatric Patients

108
Elderly individuals encompass a diverse population with varying degrees of age-related physiological changes. Defining the elderly presents challenges, as the geriatric population is often arbitrarily categorized as individuals older than 65. However, many individuals in this group lead active and healthy lives, with an increasing number surpassing 85 years and falling into the older elderly category. Physiological changes associated with aging impact performance capacity and homeostatic...
108
Aneurysm III: Interprofessional Care01:26

Aneurysm III: Interprofessional Care

112
Aneurysm management involves either conservative medical therapy or surgical intervention, depending on the size and symptoms of the aneurysm. Conservative management is generally reserved for smaller, asymptomatic aneurysms, while larger or symptomatic aneurysms often necessitate surgical repair.Conservative Medical TherapyFor small, asymptomatic aneurysms, particularly abdominal aortic aneurysms (AAA) less than 5.5 centimeters in diameter, conservative medical therapy is recommended. This...
112
Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Absorption01:22

Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Absorption

98
As individuals age, their body's physiology evolves, affecting drug pharmacokinetics. The most apparent changes occur in the gastrointestinal tract, where an increase in gastric pH, a delay in gastric emptying, and a reduction in gastrointestinal motility are observed. Remarkably, these changes do not substantially modify the absorption of orally administered drugs, particularly those absorbed via passive diffusion.Transdermal drug delivery emerges as a highly viable method for older adults due...
98

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

A Regional Approach to Resource Management, Stewardship, and Outcomes Among Mild TBI Admissions: A Preliminary Report.

The American surgeon·2026
Same author

Outcomes after splenic injury in geriatric trauma: Is splenic embolization helpful?

The journal of trauma and acute care surgery·2026
Same author

Should platelet transfusion be used to reverse preinjury antiplatelet agents in traumatic brain injury? A systematic review and meta-analysis.

The journal of trauma and acute care surgery·2026
Same author

Impact of pediatric housing status and racial profile on outcomes after traumatic injury.

Journal of pediatric surgery·2026
Same author

Pediatric Massive Transfusion Protocol: A Narrative Review and Proposed Algorithm.

The American surgeon·2025
Same author

Necrotizing Soft Tissue Infections: A Surgical Perspective.

Journal of intensive care medicine·2025
Same journal

Perioperative Acute Myocardial Infarction in Non-Cardiac Operations: A National Analysis.

The American surgeon·2026
Same journal

Outcomes of Completion Cholecystectomy: Association With Patient Comorbidity in a National Database.

The American surgeon·2026
Same journal

Building the Conversation: Editorial Stewardship in Contemporary Surgical Publishing.

The American surgeon·2026
Same journal

Musculoskeletal Pain in Surgeons on Operating Days.

The American surgeon·2026
Same journal

Splenectomy During Cytoreductive Surgery: Marker of Surgical Burden or Independent Predictor of Morbidity?

The American surgeon·2026
Same journal

Predictors of a Long Hospital Stay After Abdominoperineal Resection of Rectal Cancer: Analysis of the National Cancer Database.

The American surgeon·2026
See all related articles

Related Experiment Video

Updated: Nov 23, 2025

A Preclinical Controlled Cortical Impact Model for Traumatic Hemorrhage Contusion and Neuroinflammation
06:50

A Preclinical Controlled Cortical Impact Model for Traumatic Hemorrhage Contusion and Neuroinflammation

Published on: June 10, 2020

2.1K

Geriatric Trauma Mortality: Does Trauma Center Level Matter?

Frederick B Rogers1, Madison E Morgan1, Catherine Ting Brown1

  • 1Trauma and Acute Care Surgery, 209639Penn Medicine Lancaster General Health, Lancaster, PA, USA.

The American Surgeon
|December 31, 2020
PubMed
Summary
This summary is machine-generated.

Geriatric trauma patients experience similar outcomes at Level I and Level II trauma centers. This study found no significant differences in mortality, complications, or functional status, suggesting both center types can provide effective care for older adults.

Keywords:
geriatricstrauma

More Related Videos

Murine Model of Controlled Cortical Impact for the Induction of Traumatic Brain Injury
05:01

Murine Model of Controlled Cortical Impact for the Induction of Traumatic Brain Injury

Published on: August 16, 2019

10.8K
Controlled Cortical Impact Model for Traumatic Brain Injury
05:30

Controlled Cortical Impact Model for Traumatic Brain Injury

Published on: August 5, 2014

29.2K

Related Experiment Videos

Last Updated: Nov 23, 2025

A Preclinical Controlled Cortical Impact Model for Traumatic Hemorrhage Contusion and Neuroinflammation
06:50

A Preclinical Controlled Cortical Impact Model for Traumatic Hemorrhage Contusion and Neuroinflammation

Published on: June 10, 2020

2.1K
Murine Model of Controlled Cortical Impact for the Induction of Traumatic Brain Injury
05:01

Murine Model of Controlled Cortical Impact for the Induction of Traumatic Brain Injury

Published on: August 16, 2019

10.8K
Controlled Cortical Impact Model for Traumatic Brain Injury
05:30

Controlled Cortical Impact Model for Traumatic Brain Injury

Published on: August 5, 2014

29.2K

Area of Science:

  • Trauma Surgery
  • Geriatric Medicine
  • Health Services Research

Background:

  • Level II trauma centers (TCs), often in rural/suburban areas, may have more geriatric trauma patient experience.
  • This study investigated whether geriatric trauma patients have better outcomes at Level II TCs compared to Level I TCs.

Purpose of the Study:

  • To compare outcomes for geriatric trauma patients treated at Level I versus Level II trauma centers.
  • To determine if trauma center designation impacts mortality, complications, and functional status at discharge for older adults.

Main Methods:

  • Retrospective analysis of the Pennsylvania Trauma Outcome Study (PTOS) database (2003-2017) and the National Trauma Data Bank (NTDB) (2013).
  • Inclusion criteria: geriatric (age ≥65 years) trauma patients admitted to Level I or Level II TCs.
  • Multivariate logistic regression used to assess adjusted impact on mortality, complications, and functional status at discharge (FSD).

Main Results:

  • A higher proportion of geriatric trauma patients were admitted to Level II TCs (36.2%) compared to Level I TCs (29.1%) (P <.001).
  • Adjusted analysis revealed no significant differences in mortality (AOR: 1.13; P = .375), complications (AOR: 1.25; P = .080), or FSD (AOR: 1.09; P = .493) between Level I and Level II TCs.
  • NTDB analysis (n = 144,622) also showed no association between mortality and TC level (AOR: 1.04; P = .182).

Conclusions:

  • Level I and Level II trauma centers demonstrate comparable outcomes for geriatric trauma patients regarding mortality, complications, and functional status.
  • Despite a higher proportion of geriatric patients at Level II TCs, outcomes were similar, suggesting both levels of care are effective.
  • Future designations of geriatric trauma centers of excellence should consider both Level I and Level II TCs.