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Three-Dimensional Bone Extracellular Matrix Model for Osteosarcoma
Published on: April 12, 2019
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STAT3 and its targeting inhibitors in osteosarcoma
Yun Liu1,2,3, Shijie Liao2,3,4, Samuel Bennett2
1Department of Spine and Osteopathic Surgery, First Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi, China.
Cell Proliferation
|December 31, 2020
Summary
Signal transducer and activator of transcription 3 (STAT3) is a key regulator of cell growth and survival. Constitutive STAT3 activation drives osteosarcoma progression and resistance, making it a promising therapeutic target.
Area of Science:
- Molecular Biology
- Oncology
- Cell Signaling
Background:
- Signal transducer and activator of transcription 3 (STAT3) regulates cellular processes like growth, differentiation, and survival.
- STAT3 is activated by phosphorylation, dimerizes, and translocates to the nucleus to control gene transcription.
- STAT3 is implicated in various cancers and considered a proto-oncogene.
Purpose of the Study:
- To review recent advancements concerning STAT3 in osteosarcoma (OS).
- To highlight the role of STAT3 overexpression and activation in OS progression and poor prognosis.
Main Methods:
- Literature review focusing on STAT3 and osteosarcoma.
- Analysis of STAT3's role in OS cell transformation, proliferation, invasion, metastasis, immune evasion, and drug resistance.
Main Results:
- STAT3 is overexpressed in osteosarcoma and correlates with poor prognosis.
- Constitutive STAT3 activation promotes OS development by upregulating oncogenes.
- STAT3 contributes to OS cell proliferation, invasion, metastasis, immune evasion, and drug resistance.
Conclusions:
- STAT3 plays a critical role in osteosarcoma pathogenesis.
- Targeting STAT3 presents a potential therapeutic strategy for osteosarcoma treatment.
