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Updated: Aug 4, 2026
Chronic Salmonella Infected Mouse Model
Published on: May 31, 2010
Patients with CLL and hypocomplementaemia have an impaired serum bactericidal activity against the Salmonella
1National Institute of Haematology and Blood Transfusion, Budapest, Hungary.
Abstract:
The bactericidal effect of 25 serum samples from 23 patients with chronic lymphocytic leukaemia (CLL) against the Salmonella minnesota S form and Re mutant has been studied. No killing of the S form was observed in any of the sera tested, whereas a normal bactericidal effect was found against the Re mutant (group 1) in 17/25 sera of CLL patients. By contrast, in 8 serum samples from 6 CLL patients no killing or a markedly delayed killing of the Re strain was observed (group 2). Significant differences in the complement levels were found between the sera of group 1 and group 2. In group 1 mostly normal or elevated complement levels were observed, while in group 2 levels of C4 and C2 were found to be strongly decreased. A significant correlation was found between the bactericidal effect on the one hand and the C4 and C2 levels on the other.
