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Published on: May 2, 2025
Serum myeloid-related protein 8/14 is a potential predictor of diabetic kidney disease
Wensha Gu1, Jingxiang Cui2,3,4, Min Shi1
1Departments of Endocrinology and ICU, the Affiliated Huai'an No. 1 People's Hospital of Nanjing Medical University, Huai'an, Jiangsu 223300, China.
Background:
Myeloid-related protein 8/14 (MRP8/14) is secreted by macrophages and formed by MRP8 and MRP14, which is closely related to vascular inflammation. Chronic vascular inflammation plays a significant role in the development and progression of diabetic kidney disease (DKD). This study aims to investigate the relationship between MRP8/14 and DKD.
Methods:
A total of 80 individuals with type 2 diabetes were divided into four groups, according to the baseline urinary albumin/creatinine ratio (ACR) levels Serum concentrations of MRP8/14 were measured by ELISA. The clinical variables were obtained through physical examination, illness history, or laboratory evidence.
Results:
As DKD worsened, the level of serum MRP8/14 increased gradually, and MRP8/14 has a significantly positive correlation with ACR (r = 0.349, P = 0.002), body mass index (BMI) (r = 0.288, P = 0.009), serum creatinine (Cre) (r = 0.392, P < 0.001), blood urine nitrogen (BUN) (r = 0.333, P = 0.003), systolic blood pressure (SBP) (r = 0.301, P = 0.007), and a negative correlation with the estimated glomerular filtration rate (eGFR) (r = -0.478, P < 0.001). Logistic regression analysis showed that age, Cre, eGFR, ACR, and MRP8/14 were associated with the progression of DKD (P < 0.05).
Conclusions:
The serum MRP8/14 is correlated significantly with the progression of DKD, suggesting that MRP8/14 may be an independent predictor of the progression of DKD.
Insights
Serum myeloid-related protein 8/14 (MRP8/14) levels increase with diabetic kidney disease (DKD) progression. MRP8/14 may serve as an independent predictor for DKD advancement.
Area of Science:
- Nephrology
- Immunology
- Endocrinology
Background:
- Diabetic kidney disease (DKD) is a major complication of diabetes, characterized by chronic vascular inflammation.
- Myeloid-related protein 8/14 (MRP8/14), secreted by macrophages, is linked to vascular inflammation.
Purpose of the Study:
- To investigate the association between serum MRP8/14 levels and the progression of diabetic kidney disease (DKD).
Main Methods:
- 80 individuals with type 2 diabetes were stratified into four groups based on urinary albumin/creatinine ratio (ACR).
- Serum MRP8/14 concentrations were quantified using ELISA.
- Clinical variables including BMI, serum creatinine (Cre), blood urea nitrogen (BUN), systolic blood pressure (SBP), and estimated glomerular filtration rate (eGFR) were collected.
Main Results:
- Serum MRP8/14 levels showed a significant positive correlation with ACR, BMI, Cre, BUN, and SBP.
- A significant negative correlation was observed between serum MRP8/14 and eGFR.
- Logistic regression identified age, Cre, eGFR, ACR, and MRP8/14 as factors associated with DKD progression.
Conclusions:
- Serum MRP8/14 is significantly correlated with the progression of diabetic kidney disease (DKD).
- MRP8/14 shows potential as an independent predictive biomarker for DKD progression.
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