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Updated: Nov 23, 2025

Induction and Validation of Cellular Senescence in Primary Human Cells
Published on: June 20, 2018
Effects of cellular senescence on metabolic pathways in non-immune and immune cells
Daniela Frasca1, Yara Bou Saada2, Denisse Garcia3
1Department of Microbiology and Immunology, USA; Sylvester Comprehensive Cancer Center, University of Miami Miller School of Medicine, Miami, FL, USA.
Abstract:
Many cellular stresses induce cellular senescence and the irreversible arrest of cell proliferation in different cell types. Although blocked in their capacity to divide, senescent cells are metabolically active and are characterized by a different metabolic phenotype as compared to non-senescent cells. Changes observed in senescent cells depend from the cell type and lead to an adaptative flexibility in the type of metabolism. This metabolic reprogramming is needed to cope with survival and with the energetic demands of the senescent program that include the increased secretion of senescence-associated secretory phenotype factors.
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