Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Ultrasound II: Endoscopic Ultrasound and FibroScan01:25

Ultrasound II: Endoscopic Ultrasound and FibroScan

316
Endoscopic Ultrasound (EUS) and FibroScan are valuable diagnostic tools in gastroenterology and hepatology, each with specific applications and techniques.
Endoscopic Ultrasound (EUS):
316
Liver Regeneration01:24

Liver Regeneration

3.9K
The liver is an important organ in vertebrates that plays an essential role in metabolism. It is also responsible for storing and redistributing nutrients such as carbohydrates, fats, and vitamins in the body. Additionally, the liver releases bile salts which are critical for digesting food and eliminating toxic metabolites from the body.
Cells of Liver
The liver comprises four major types of cells— hepatocytes, stellate, Kupffer, and sinusoidal endothelial cells. The hepatocytes are...
3.9K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

A High-Potency Protein That Normalizes Body Weight in DIO Mice through Triple Agonism at FGF21, GLP1, and GIP Receptors.

Biochemistry·2026
Same author

LC-MS measurement of triglyceride hydrolysis: Application in studies of Patatin-like phospholipase domain-containing protein 3 activity.

Analytical biochemistry·2026
Same author

AI-assisted fibrosis scoring in MASH: Exploring pathologist decision-making with an SHG-based AI digital pathology tool.

JHEP reports : innovation in hepatology·2026
Same author

CLCC1 promotes hepatic neutral lipid flux and nuclear pore complex assembly.

Nature·2026
Same author

A mitochondrial amidoxime-reducing component 1 (mARC1) A168T amino acid substitution does not confer protection from MASH and fibrosis in multiple mouse models of chronic liver disease.

The Biochemical journal·2025
Same author

Whole body and hematopoietic cell-specific deletion of G-protein coupled receptor 65 (GPR65) improves insulin sensitivity in diet-induced obese mice.

Molecular metabolism·2025

Related Experiment Video

Updated: Nov 23, 2025

Optimized Analysis of In Vivo and In Vitro Hepatic Steatosis
08:58

Optimized Analysis of In Vivo and In Vitro Hepatic Steatosis

Published on: March 11, 2017

16.5K

FGF19 and FGF21: In NASH we trust.

Saswata Talukdar1, Alexei Kharitonenkov2

  • 1Merck & Co., Inc., 213 East Grand Avenue, South San Francisco, CA, 94080, United States.

Molecular Metabolism
|December 31, 2020
PubMed
Summary

Fibroblast Growth Factor (FGF) analogs FGF19 and FGF21 show therapeutic potential. Analysis of preclinical and clinical data provides insights into their mechanisms, pharmacokinetics, pharmacodynamics, and efficacy in ongoing research.

Keywords:
Clinical trialsDrug developmentFGF19FGF21MetabolismNASH

More Related Videos

Novel In Vivo Micro-Computed Tomography Imaging Techniques for Assessing the Progression of Non-Alcoholic Fatty Liver Disease
08:41

Novel In Vivo Micro-Computed Tomography Imaging Techniques for Assessing the Progression of Non-Alcoholic Fatty Liver Disease

Published on: March 24, 2023

1.5K
Author Spotlight: Establishing MASLD Cell Models for Investigating Disease Mechanisms and the Lipid-Lowering Effects of Koumiss
07:03

Author Spotlight: Establishing MASLD Cell Models for Investigating Disease Mechanisms and the Lipid-Lowering Effects of Koumiss

Published on: July 19, 2024

1.3K

Related Experiment Videos

Last Updated: Nov 23, 2025

Optimized Analysis of In Vivo and In Vitro Hepatic Steatosis
08:58

Optimized Analysis of In Vivo and In Vitro Hepatic Steatosis

Published on: March 11, 2017

16.5K
Novel In Vivo Micro-Computed Tomography Imaging Techniques for Assessing the Progression of Non-Alcoholic Fatty Liver Disease
08:41

Novel In Vivo Micro-Computed Tomography Imaging Techniques for Assessing the Progression of Non-Alcoholic Fatty Liver Disease

Published on: March 24, 2023

1.5K
Author Spotlight: Establishing MASLD Cell Models for Investigating Disease Mechanisms and the Lipid-Lowering Effects of Koumiss
07:03

Author Spotlight: Establishing MASLD Cell Models for Investigating Disease Mechanisms and the Lipid-Lowering Effects of Koumiss

Published on: July 19, 2024

1.3K

Area of Science:

  • Endocrinology
  • Pharmacology

Background:

  • Fibroblast Growth Factor 19 (FGF19) and FGF21 are endocrine factors with significant therapeutic promise.
  • Multiple therapeutic assets targeting the FGF receptor (FGFR)/beta-klotho (KLB) pathway are in development.

Purpose of the Study:

  • To provide a comprehensive analysis of preclinical and clinical data for FGF19 and FGF21 analogs.
  • To offer insights into the mechanism of action, pharmacokinetics (PK), pharmacodynamics (PD), and efficacy of clinical assets.

Main Methods:

  • Systematic review and detailed analysis of published preclinical (rodent, non-human primate) and clinical data.
  • Evaluation of mechanistic insights, PK/PD, and efficacy data from available literature.

Main Results:

  • Mechanistic insights were derived from preclinical studies in rodents and non-human primates.
  • Pharmacodynamic data from clinical studies were analyzed to understand drug effects.
  • Multiple FGF19 and FGF21 analogs are advancing, with some entering Phase 3 clinical trials.

Conclusions:

  • The scientific understanding and application of endocrine FGFs have advanced significantly.
  • FGF19 and FGF21 analogs represent a rapidly evolving area of therapeutic development, nearing late-stage clinical validation.