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[Epidemiological research on primary hyperparathyroidism. A prospective multicenter study].

B Niederle1, R Roka, W Woloszczuk

  • 1I. Chirurgische Universitätsklinik, Ludwig-Boltzmann-Institut für Klinische Endokrinologie, Wien.

Deutsche Medizinische Wochenschrift (1946)
|February 5, 1988
PubMed
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Hypercalcemia affects 0.64% of hospitalized patients. Primary hyperparathyroidism is a common cause, necessitating its consideration in differential diagnoses for elevated serum calcium levels.

Area of Science:

  • Endocrinology
  • Clinical Biochemistry

Background:

  • Hypercalcemia is a significant clinical finding with diverse etiologies.
  • Accurate diagnosis is crucial for appropriate patient management.

Purpose of the Study:

  • To investigate the prevalence and causes of hypercalcemia in a large cohort of hospitalized patients.
  • To determine the diagnostic yield of investigating hypercalcemia and the contribution of primary hyperparathyroidism.

Main Methods:

  • Serum calcium levels were analyzed in 11,588 hospitalized patients over a 12-month period.
  • Patients with hypercalcemia underwent further clinical and biochemical investigations.
  • Etiologies were categorized based on established diagnostic criteria.

Main Results:

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  • Hypercalcemia was identified in 74 patients (0.64%).
  • Primary hyperparathyroidism was diagnosed in 20 patients (27% of hypercalcemic cases).
  • Malignancy was the cause in 15 patients (20%), with bone metastases in six.

Conclusions:

  • Primary hyperparathyroidism is a prevalent cause of hypercalcemia in hospitalized individuals.
  • Consideration of parathyroid hyperfunction is essential in the differential diagnosis of hypercalcemia due to its varied clinical presentations.